Fine‐needle aspiration cytology of mammary adenomyoepithelioma: Report of a case with intranuclear cytoplasmic inclusions

Philip T. Valente, John H. Stuckey

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Adenomyoepithelioma of the breast is an uncommon lesion which may recur and rarely metastasizes. We report the fine‐needle aspiration (FNA) findings in one case of mammary adenomyoepithelioma in which this tumor's unusual cytomorphology led to a cytologic diagnosis of malignancy, possibly metastatic to the breast. Large, atypical, polygonal cells, some with intranuclear cytoplasmic inclusions, were most worrisome cytologically, but corresponded in the biopsied specimen to cells immunohistochemically documented to be of myoepithelial origin. Nests of epithelium and myoepithelial cells sometimes embedded in fibrous, stromal fragments were suggestive of an infiltrating pattern. Recognition of such unusual features in breast FNA is most important since definitive therapy may follow an FNA diagnosis of carcinoma in some clinical settings. In cases with unusual morphology, surgical biopsy should be recommended to clarify the nature of the lesion. © 1994 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalDiagnostic cytopathology
Volume10
Issue number2
DOIs
StatePublished - Mar 1994

Keywords

  • Adenomyoepithelioma
  • Breast aspiration cytology
  • Immunohistochemistry
  • Intranuclear inclusions
  • Morphology
  • Stromal fragments

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Fingerprint Dive into the research topics of 'Fine‐needle aspiration cytology of mammary adenomyoepithelioma: Report of a case with intranuclear cytoplasmic inclusions'. Together they form a unique fingerprint.

Cite this