Fine-needle aspiration findings of Xp11 translocation renal cell carcinoma metastatic to a hilar lymph node

Reima El Naili, Marlo Nicolas, Amanda Gorena, Maria Luisa C. Policarpio-Nicolas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Xp11 translocation renal cell carcinoma (RCC) is a specific type of renal cell carcinoma recently placed under the “MiT family translocation RCC” at the last 2013 ISUP Vancouver classification of renal neoplasia. This tumor contains variable proportions of clear cells and could easily mimic papillary RCC, clear cell type, and clear cell papillary RCC. Given the small number of published cytologic findings of this tumor, it could easily present as a diagnostic pitfall. We describe a case of a 23-year-old man with a history of prior nephrectomy who presented with multiple mediastinal lymphadenopathies on imaging surveillance follow-up. Fine-needle aspiration of the lymph node showed tumor cells with voluminous clear to eosinophilic cytoplasm, well-defined cell borders and hyperchromatic nuclei arranged in papillary architecture. Review of the prior nephrectomy specimen showed papillary cores surrounded by cells with voluminous clear to finely granular eosinophilic cytoplasm and distinct cell borders. Immunohistochemical stains performed on the nephrectomy specimen showed tumor positivity for CD10, E-cadherin, a-methylacyl coenzyme A racemase, and TFE3 supporting the diagnosis of Xp11 translocation renal cell carcinoma. Although this tumor was initially described predominantly in children, it could also occur in adults, as seen in this case. Familiarity with the cytologic findings of this tumor, use of immunohistochemical stains, or cytogenetic test to determine the type of gene fusion will be extremely useful in arriving at the correct diagnosis. Diagn. Cytopathol. 2017;45:456–462.

Original languageEnglish (US)
Pages (from-to)456-462
Number of pages7
JournalDiagnostic Cytopathology
Volume45
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Fine Needle Biopsy
Renal Cell Carcinoma
Lymph Nodes
Nephrectomy
Neoplasms
Cytoplasm
Coloring Agents
Racemases and Epimerases
Gene Fusion
Cadherins
Coenzyme A
Cytogenetics
Kidney

Keywords

  • aspiration cytology
  • Xp11 translocation RCC

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Fine-needle aspiration findings of Xp11 translocation renal cell carcinoma metastatic to a hilar lymph node. / El Naili, Reima; Nicolas, Marlo; Gorena, Amanda; Policarpio-Nicolas, Maria Luisa C.

In: Diagnostic Cytopathology, Vol. 45, No. 5, 01.05.2017, p. 456-462.

Research output: Contribution to journalArticle

El Naili, Reima ; Nicolas, Marlo ; Gorena, Amanda ; Policarpio-Nicolas, Maria Luisa C. / Fine-needle aspiration findings of Xp11 translocation renal cell carcinoma metastatic to a hilar lymph node. In: Diagnostic Cytopathology. 2017 ; Vol. 45, No. 5. pp. 456-462.
@article{c3a3175c545540a6be9be46d152435e7,
title = "Fine-needle aspiration findings of Xp11 translocation renal cell carcinoma metastatic to a hilar lymph node",
abstract = "Xp11 translocation renal cell carcinoma (RCC) is a specific type of renal cell carcinoma recently placed under the “MiT family translocation RCC” at the last 2013 ISUP Vancouver classification of renal neoplasia. This tumor contains variable proportions of clear cells and could easily mimic papillary RCC, clear cell type, and clear cell papillary RCC. Given the small number of published cytologic findings of this tumor, it could easily present as a diagnostic pitfall. We describe a case of a 23-year-old man with a history of prior nephrectomy who presented with multiple mediastinal lymphadenopathies on imaging surveillance follow-up. Fine-needle aspiration of the lymph node showed tumor cells with voluminous clear to eosinophilic cytoplasm, well-defined cell borders and hyperchromatic nuclei arranged in papillary architecture. Review of the prior nephrectomy specimen showed papillary cores surrounded by cells with voluminous clear to finely granular eosinophilic cytoplasm and distinct cell borders. Immunohistochemical stains performed on the nephrectomy specimen showed tumor positivity for CD10, E-cadherin, a-methylacyl coenzyme A racemase, and TFE3 supporting the diagnosis of Xp11 translocation renal cell carcinoma. Although this tumor was initially described predominantly in children, it could also occur in adults, as seen in this case. Familiarity with the cytologic findings of this tumor, use of immunohistochemical stains, or cytogenetic test to determine the type of gene fusion will be extremely useful in arriving at the correct diagnosis. Diagn. Cytopathol. 2017;45:456–462.",
keywords = "aspiration cytology, Xp11 translocation RCC",
author = "{El Naili}, Reima and Marlo Nicolas and Amanda Gorena and Policarpio-Nicolas, {Maria Luisa C.}",
year = "2017",
month = "5",
day = "1",
doi = "10.1002/dc.23676",
language = "English (US)",
volume = "45",
pages = "456--462",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - Fine-needle aspiration findings of Xp11 translocation renal cell carcinoma metastatic to a hilar lymph node

AU - El Naili, Reima

AU - Nicolas, Marlo

AU - Gorena, Amanda

AU - Policarpio-Nicolas, Maria Luisa C.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Xp11 translocation renal cell carcinoma (RCC) is a specific type of renal cell carcinoma recently placed under the “MiT family translocation RCC” at the last 2013 ISUP Vancouver classification of renal neoplasia. This tumor contains variable proportions of clear cells and could easily mimic papillary RCC, clear cell type, and clear cell papillary RCC. Given the small number of published cytologic findings of this tumor, it could easily present as a diagnostic pitfall. We describe a case of a 23-year-old man with a history of prior nephrectomy who presented with multiple mediastinal lymphadenopathies on imaging surveillance follow-up. Fine-needle aspiration of the lymph node showed tumor cells with voluminous clear to eosinophilic cytoplasm, well-defined cell borders and hyperchromatic nuclei arranged in papillary architecture. Review of the prior nephrectomy specimen showed papillary cores surrounded by cells with voluminous clear to finely granular eosinophilic cytoplasm and distinct cell borders. Immunohistochemical stains performed on the nephrectomy specimen showed tumor positivity for CD10, E-cadherin, a-methylacyl coenzyme A racemase, and TFE3 supporting the diagnosis of Xp11 translocation renal cell carcinoma. Although this tumor was initially described predominantly in children, it could also occur in adults, as seen in this case. Familiarity with the cytologic findings of this tumor, use of immunohistochemical stains, or cytogenetic test to determine the type of gene fusion will be extremely useful in arriving at the correct diagnosis. Diagn. Cytopathol. 2017;45:456–462.

AB - Xp11 translocation renal cell carcinoma (RCC) is a specific type of renal cell carcinoma recently placed under the “MiT family translocation RCC” at the last 2013 ISUP Vancouver classification of renal neoplasia. This tumor contains variable proportions of clear cells and could easily mimic papillary RCC, clear cell type, and clear cell papillary RCC. Given the small number of published cytologic findings of this tumor, it could easily present as a diagnostic pitfall. We describe a case of a 23-year-old man with a history of prior nephrectomy who presented with multiple mediastinal lymphadenopathies on imaging surveillance follow-up. Fine-needle aspiration of the lymph node showed tumor cells with voluminous clear to eosinophilic cytoplasm, well-defined cell borders and hyperchromatic nuclei arranged in papillary architecture. Review of the prior nephrectomy specimen showed papillary cores surrounded by cells with voluminous clear to finely granular eosinophilic cytoplasm and distinct cell borders. Immunohistochemical stains performed on the nephrectomy specimen showed tumor positivity for CD10, E-cadherin, a-methylacyl coenzyme A racemase, and TFE3 supporting the diagnosis of Xp11 translocation renal cell carcinoma. Although this tumor was initially described predominantly in children, it could also occur in adults, as seen in this case. Familiarity with the cytologic findings of this tumor, use of immunohistochemical stains, or cytogenetic test to determine the type of gene fusion will be extremely useful in arriving at the correct diagnosis. Diagn. Cytopathol. 2017;45:456–462.

KW - aspiration cytology

KW - Xp11 translocation RCC

UR - http://www.scopus.com/inward/record.url?scp=85012096162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012096162&partnerID=8YFLogxK

U2 - 10.1002/dc.23676

DO - 10.1002/dc.23676

M3 - Article

C2 - 28185421

AN - SCOPUS:85012096162

VL - 45

SP - 456

EP - 462

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

IS - 5

ER -