Finding robust linear expression-based classifiers

Seungchan Kim, Edward R. Dougherty, Junior Barrera, Y. Chen, M. Bittner, J. M. Trent

Research output: Contribution to journalArticle

Abstract

A key goal for the use of gene-expression microarrays is to perform classification via different expression patterns. The typical small sample obtained and the large numbers of variables make the task of finding good classifiers extremely difficult, from the perspectives of both design and error estimation. This paper addresses the issue of estimation variability, which can result in large numbers of gene sets that have highly optimistic error estimates. It proposes performing classification on probability distributions derived from the original sample points by spreading the mass of those points to make classification more difficult while retaining the basic geometry of the point locations. This is done in a parameterized fashion, based on the degree to which the mass is spread. The method is applied to linear classifiers.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4266
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

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Keywords

  • Classification
  • Genomics
  • Linear classifier
  • Microarray
  • Perceptron

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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