Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics

Catherine Diamante, Monice Zondlo Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dilauryl thiodipropionate (DLTDP), dicetyl thiodipropionate, dimyristyl thiodipropionate, distearyl thiodipropionate, and ditridecyl thiodipropionate are dialkyl esters of their respective alcohols and thiodipropionic acid (TDPA) used in cosmetics. Ingested DLTDP was excreted in the urine as TDPA. Single-dose acute oral and parenteral studies and subchronic and chronic repeated dose oral studies did not suggest significant toxicity. Neither DLTDP nor TDPA was irritating to animal skin or eyes and they were not sensitizers. TDPA was neither a teratogen nor a reproductive toxicant. Genotoxicity studies were negative for TDPA and DLTDP. Clinical testing demonstrated some evidence of irritation but no sensitization or photosensitization. The Cosmetic Ingredient Review Expert Panel considered that the data from DLTDP reasonably may be extrapolated to the other dialkyl esters and concluded that these ingredients were safe for use in cosmetic products that are formulated to be nonirritating.

Original languageEnglish (US)
JournalInternational Journal of Toxicology
Volume29
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Cosmetics
Esters
Safety
Teratogens
Photosensitivity Disorders
Toxicity
Skin
Animals
Alcohols
thiodipropionic acid
Urine
Testing

Keywords

  • cosmetics
  • dilauryl thiodipropionate
  • safety

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

Cite this

Diamante, C., Zondlo Fiume, M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... Andersen, F. A. (2010). Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics. International Journal of Toxicology, 29(4). https://doi.org/10.1177/1091581810373150

Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics. / Diamante, Catherine; Zondlo Fiume, Monice; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J; Snyder, Paul W.; Andersen, F. Alan.

In: International Journal of Toxicology, Vol. 29, No. 4, 2010.

Research output: Contribution to journalArticle

Diamante, C, Zondlo Fiume, M, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2010, 'Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics', International Journal of Toxicology, vol. 29, no. 4. https://doi.org/10.1177/1091581810373150
Diamante, Catherine ; Zondlo Fiume, Monice ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J ; Snyder, Paul W. ; Andersen, F. Alan. / Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics. In: International Journal of Toxicology. 2010 ; Vol. 29, No. 4.
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