Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate

Valerie Robinson, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are used in cosmetics as fragrance ingredients and/or solvents at concentrations of 0.4% to 2%. Propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure, but the inhalation toxicity of PPG-2 methyl ether vapor, for example, is low. Aerosols, such as found with hair sprays, produce particle sizes that are not respirable. Because these ingredients are highly water-soluble, They are likely to be absorbed through the human skin only at slow rates, resulting in low blood concentrations and rapid removal by the kidney. These ingredients are not genotoxic and are not reproductive or developmental toxicants. Overall the data are sufficient to conclude that PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are safe as used in cosmetics.

Original languageEnglish (US)
Pages (from-to)162S-174S
JournalInternational journal of toxicology
Volume28
Issue number6_suppl
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Cosmetics
  • PPG-2 methyl ether
  • PPG-2 methyl ether acetate
  • PPG-3 methyl ether
  • Safety

ASJC Scopus subject areas

  • Toxicology

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