Final report of the safety assessment of methylisothiazolinone

Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.01%) or less would not be expected to pose a sensitization risk. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration.

Original languageEnglish (US)
JournalInternational Journal of Toxicology
Volume29
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Cosmetics
Safety
Animals
Heterocyclic Compounds
Xylenes
Odors
Hexanes
Organic compounds
Solubility
Methanol
2-methyl-4-isothiazolin-3-one
Skin
Water
Liquids

Keywords

  • cosmetics
  • methylisothiazolinone
  • safety

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

Cite this

Burnett, C. L., Bergfeld, W. F., Belsito, D. V., Klaassen, C. D., Marks, J. G., Shank, R. C., ... Andersen, F. A. (2010). Final report of the safety assessment of methylisothiazolinone. International Journal of Toxicology, 29(4). https://doi.org/10.1177/1091581810374651

Final report of the safety assessment of methylisothiazolinone. / Burnett, Christina L.; Bergfeld, Wilma F.; Belsito, Donald V.; Klaassen, Curtis D.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J; Snyder, Paul W.; Andersen, F. Alan.

In: International Journal of Toxicology, Vol. 29, No. 4, 2010.

Research output: Contribution to journalArticle

Burnett, CL, Bergfeld, WF, Belsito, DV, Klaassen, CD, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2010, 'Final report of the safety assessment of methylisothiazolinone', International Journal of Toxicology, vol. 29, no. 4. https://doi.org/10.1177/1091581810374651
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG, Shank RC et al. Final report of the safety assessment of methylisothiazolinone. International Journal of Toxicology. 2010;29(4). https://doi.org/10.1177/1091581810374651
Burnett, Christina L. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Klaassen, Curtis D. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J ; Snyder, Paul W. ; Andersen, F. Alan. / Final report of the safety assessment of methylisothiazolinone. In: International Journal of Toxicology. 2010 ; Vol. 29, No. 4.
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