Final report of the safety assessment of cosmetic ingredients derived from Zea Mays (Corn)

F. Alan Andersen, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Many cosmetic ingredients are derived from Zea mays (corn). While safety test data were not available for most ingredients, similarities in preparation and the resulting similar composition allowed extrapolation of safety data to all listed ingredients. Animal studies included acute toxicity, ocular and dermal irritation studies, and dermal sensitization studies. Clinical studies included dermal irritation and sensitization. Case reports were available for the starch as used as a donning agent in medical gloves. Studies of many other endpoints, including reproductive and developmental toxicity, use corn oil as a vehicle control with no reported adverse effects at levels used in cosmetics. While industry should continue limiting ingredient impurities such as pesticide residues before blending into a cosmetic formulation, the CIR Expert Panel determined that corn-derived ingredients are safe for use in cosmetics in the practices of use and concentration described in the assessment.

Original languageEnglish (US)
JournalInternational Journal of Toxicology
Volume30
Issue number3
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Cosmetics
Zea mays
Safety
Toxicity
Skin
Pesticide Residues
Corn Oil
Extrapolation
Starch
Animals
Impurities
Industry
Chemical analysis

Keywords

  • cosmetics
  • safety
  • Zea mays (corn)

ASJC Scopus subject areas

  • Toxicology

Cite this

Andersen, F. A., Bergfeld, W. F., Belsito, D. V., Klaassen, C. D., Marks, J. G., Shank, R. C., ... Snyder, P. W. (2011). Final report of the safety assessment of cosmetic ingredients derived from Zea Mays (Corn). International Journal of Toxicology, 30(3). https://doi.org/10.1177/1091581811403832

Final report of the safety assessment of cosmetic ingredients derived from Zea Mays (Corn). / Andersen, F. Alan; Bergfeld, Wilma F.; Belsito, Donald V.; Klaassen, Curtis D.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J; Snyder, Paul W.

In: International Journal of Toxicology, Vol. 30, No. 3, 05.2011.

Research output: Contribution to journalArticle

Andersen, F. Alan ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Klaassen, Curtis D. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J ; Snyder, Paul W. / Final report of the safety assessment of cosmetic ingredients derived from Zea Mays (Corn). In: International Journal of Toxicology. 2011 ; Vol. 30, No. 3.
@article{5a5e5c6bc02b4378a15f49f82722c583,
title = "Final report of the safety assessment of cosmetic ingredients derived from Zea Mays (Corn)",
abstract = "Many cosmetic ingredients are derived from Zea mays (corn). While safety test data were not available for most ingredients, similarities in preparation and the resulting similar composition allowed extrapolation of safety data to all listed ingredients. Animal studies included acute toxicity, ocular and dermal irritation studies, and dermal sensitization studies. Clinical studies included dermal irritation and sensitization. Case reports were available for the starch as used as a donning agent in medical gloves. Studies of many other endpoints, including reproductive and developmental toxicity, use corn oil as a vehicle control with no reported adverse effects at levels used in cosmetics. While industry should continue limiting ingredient impurities such as pesticide residues before blending into a cosmetic formulation, the CIR Expert Panel determined that corn-derived ingredients are safe for use in cosmetics in the practices of use and concentration described in the assessment.",
keywords = "cosmetics, safety, Zea mays (corn)",
author = "Andersen, {F. Alan} and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Klaassen, {Curtis D.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J} and Snyder, {Paul W.}",
year = "2011",
month = "5",
doi = "10.1177/1091581811403832",
language = "English (US)",
volume = "30",
journal = "International Journal of Toxicology",
issn = "1091-5818",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - Final report of the safety assessment of cosmetic ingredients derived from Zea Mays (Corn)

AU - Andersen, F. Alan

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Klaassen, Curtis D.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J

AU - Snyder, Paul W.

PY - 2011/5

Y1 - 2011/5

N2 - Many cosmetic ingredients are derived from Zea mays (corn). While safety test data were not available for most ingredients, similarities in preparation and the resulting similar composition allowed extrapolation of safety data to all listed ingredients. Animal studies included acute toxicity, ocular and dermal irritation studies, and dermal sensitization studies. Clinical studies included dermal irritation and sensitization. Case reports were available for the starch as used as a donning agent in medical gloves. Studies of many other endpoints, including reproductive and developmental toxicity, use corn oil as a vehicle control with no reported adverse effects at levels used in cosmetics. While industry should continue limiting ingredient impurities such as pesticide residues before blending into a cosmetic formulation, the CIR Expert Panel determined that corn-derived ingredients are safe for use in cosmetics in the practices of use and concentration described in the assessment.

AB - Many cosmetic ingredients are derived from Zea mays (corn). While safety test data were not available for most ingredients, similarities in preparation and the resulting similar composition allowed extrapolation of safety data to all listed ingredients. Animal studies included acute toxicity, ocular and dermal irritation studies, and dermal sensitization studies. Clinical studies included dermal irritation and sensitization. Case reports were available for the starch as used as a donning agent in medical gloves. Studies of many other endpoints, including reproductive and developmental toxicity, use corn oil as a vehicle control with no reported adverse effects at levels used in cosmetics. While industry should continue limiting ingredient impurities such as pesticide residues before blending into a cosmetic formulation, the CIR Expert Panel determined that corn-derived ingredients are safe for use in cosmetics in the practices of use and concentration described in the assessment.

KW - cosmetics

KW - safety

KW - Zea mays (corn)

UR - http://www.scopus.com/inward/record.url?scp=79960688828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960688828&partnerID=8YFLogxK

U2 - 10.1177/1091581811403832

DO - 10.1177/1091581811403832

M3 - Article

VL - 30

JO - International Journal of Toxicology

JF - International Journal of Toxicology

SN - 1091-5818

IS - 3

ER -