Final report of the cosmetic ingredient review expert panel amended safety assessment of calendula officinalis-derived cosmetic ingredients

F. Alan Andersen, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Calendula officinalis extract, C officinalis flower, C officinalis flower extract, C officinalis flower oil, and C officinalis seed oil are cosmetic ingredients derived from C officinalis. These ingredients may contain minerals, carbohydrates, lipids, phenolic acids, flavonoids, tannins, coumarins, sterols and steroids, monoterpenes, sesquiterpenes, triterpenes, tocopherols, quinones, amino acids, and resins. These ingredients were not significantly toxic in single-dose oral studies using animals. The absence of reproductive/ developmental toxicity was inferred from repeat-dose studies of coriander oil, with a similar composition. Overall, these ingredients were not genotoxic. They also were not irritating, sensitizing, or photosensitizing in animal or clinical tests but may be mild ocular irritants. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that these ingredients are safe for use in cosmetics in the practices of use and concentration given in this amended safety assessment.

Original languageEnglish (US)
JournalInternational Journal of Toxicology
Volume29
Issue number6
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Calendula
Cosmetics
Oils
Safety
Animals
Coriandrum
Coumarins
Oilseeds
Quinones
Triterpenes
Monoterpenes
Tocopherols
Sesquiterpenes
Irritants
Poisons
Tannins
Sterols
Flavonoids
Minerals
Toxicity

Keywords

  • calendula
  • cosmetics
  • safety

ASJC Scopus subject areas

  • Toxicology

Cite this

Final report of the cosmetic ingredient review expert panel amended safety assessment of calendula officinalis-derived cosmetic ingredients. / Andersen, F. Alan; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J; Snyder, Paul W.

In: International Journal of Toxicology, Vol. 29, No. 6, 11.2010.

Research output: Contribution to journalArticle

Andersen, F. Alan ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J ; Snyder, Paul W. / Final report of the cosmetic ingredient review expert panel amended safety assessment of calendula officinalis-derived cosmetic ingredients. In: International Journal of Toxicology. 2010 ; Vol. 29, No. 6.
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