Final report of the amended safety assessment of Quaternium-15 as used in cosmetics.

Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, Ronald Hill, Daniel Leibler, James G. Marks, Ronald C. Shank, Thomas J Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Quaternium-15 is an antimicrobial agent used in cosmetics as a cosmetic preservative and antistatic agent. Little systemic toxicity was reported in most single-dose or repeated-dose animal studies. Quaternium-15 was an oral teratogen, but not a dermal teratogen, in rats at doses that exceeded the expected cumulative exposure from cosmetics. The frequency of sensitization increased in North America but not in Europe, where Quaternium-15 is used less often. In almost all animal and human studies, Quaternium-15 at 0.2% was not a sensitizer. The weight of evidence suggested that a 0.2% concentration is not a sensitizer and that cosmetic products containing Quaternium-15 up to that level are safe.

Original languageEnglish (US)
JournalInternational Journal of Toxicology
Volume29
Issue number3 Suppl
DOIs
StatePublished - May 2010
Externally publishedYes

Fingerprint

Cosmetics
Safety
Teratogens
Antistatic Agents
Animals
North America
Anti-Infective Agents
Toxicity
Rats
quaternium-15
Weights and Measures
Skin

ASJC Scopus subject areas

  • Toxicology

Cite this

Becker, L. C., Bergfeld, W. F., Belsito, D. V., Klaassen, C. D., Hill, R., Leibler, D., ... Alan Andersen, F. (2010). Final report of the amended safety assessment of Quaternium-15 as used in cosmetics. International Journal of Toxicology, 29(3 Suppl). https://doi.org/10.1177/1091581810363915

Final report of the amended safety assessment of Quaternium-15 as used in cosmetics. / Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, Donald V.; Klaassen, Curtis D.; Hill, Ronald; Leibler, Daniel; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J; Snyder, Paul W.; Alan Andersen, F.

In: International Journal of Toxicology, Vol. 29, No. 3 Suppl, 05.2010.

Research output: Contribution to journalArticle

Becker, LC, Bergfeld, WF, Belsito, DV, Klaassen, CD, Hill, R, Leibler, D, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW & Alan Andersen, F 2010, 'Final report of the amended safety assessment of Quaternium-15 as used in cosmetics.', International Journal of Toxicology, vol. 29, no. 3 Suppl. https://doi.org/10.1177/1091581810363915
Becker, Lillian C. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Klaassen, Curtis D. ; Hill, Ronald ; Leibler, Daniel ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J ; Snyder, Paul W. ; Alan Andersen, F. / Final report of the amended safety assessment of Quaternium-15 as used in cosmetics. In: International Journal of Toxicology. 2010 ; Vol. 29, No. 3 Suppl.
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