Filamentous tau pathology in nerve cells, astrocytes, and oligodendrocytes of aged baboons

Christian Schultz, Faramarz Dehghani, Gene B. Hubbard, Dietmar R. Thal, Gernot Struckhoff, Eva Braak, Heiko Braak

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Intracellular filamentous inclusions containing abnormally phosphorylated tau protein are hallmarks of several human neurodegenerative disorders. This study reveals tau-positive cytoskeletal abnormalities in neurons and glial cells of aged baboons. The brains of four baboons (Papio hamadryas, 20-30 yr of age) were examined using the Gallyas silver technique for neurofibrillary changes and phosphorylation-dependent anti-tau antibodies (AT8, AT100, AT270, PHF-1, TG3). Conspicuous changes were noted in two animals, 26 and 30 yr of age. In both animals, a combination of neuronal and glial cytoskeletal pathology was seen preferentially affecting limbic brain areas, including the hippocampal formation. In the 30-yr-old animal, numerous tau-positive inclusions were seen in the granule cells of the fascia dentata. These cells even exhibited an accumulation of argyrophilic neurofibrillary tangles. The glial changes affected both astrocytes and oligodendrocytes. Tau-positive astrocytes were seen in perivascular, subpial, and subependymal locations. Tau-positive oligodendrocytes preferentially occurred in limbic fiber tracts including the entorhinal perforant path. Ultrastructurally, tau- positive straight filaments (10-14 nm) in both neurons and glial cells were revealed by anti-tau immunoelectron microscopy. This study thus indicates the potential usefulness of aged baboons for experimental investigation of neuronal and glial filamentous tau pathology. This nonhuman primate species may provide valuable information pertinent to the broad spectrum of human tauopathies.

Original languageEnglish (US)
Pages (from-to)39-52
Number of pages14
JournalJournal of Neuropathology and Experimental Neurology
Volume59
Issue number1
DOIs
StatePublished - Jan 2000
Externally publishedYes

Keywords

  • Animal model
  • Baboon
  • Nonhuman primates
  • Tan-protein
  • Tau pathology
  • Tau-positive glial inclusions

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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