TY - JOUR
T1 - Fifteen-year results of breast-conserving surgery and definitive breast irradiation for the treatment of ductal carcinoma in situ of the breast
AU - Solin, L. J.
AU - Kurtz, J.
AU - Fourquet, A.
AU - Amalric, R.
AU - Recht, A.
AU - Bornstein, B. A.
AU - Kuske, R.
AU - Taylor, M.
AU - Barrett, W.
AU - Fowble, B.
AU - Haffty, B.
AU - Schultz, D. J.
AU - Yeh, I. T.
AU - McCormick, B.
AU - McNeese, M.
PY - 1996/3
Y1 - 1996/3
N2 - Purpose: To determine the 15-year outcome for women with ductal carcinoma in situ (DCIS, intraductal carcinoma) of the breast treated with breast- conserving surgery followed by definitive breast irradiation. Patients and Methods: An analysis was performed of 270 intraductal breast carcinomas in 268 women from 10 institutions in Europe and the United States. In all patients, breast-conserving surgery included complete gross excision of the primary tumor followed by definitive breast irradiation. When performed, pathologic axillary lymph node staging was node-negative (n = 86). The median follow-up time was 10.3 years (range, 0.9 to 26.8). Results: The 15-year actuarial overall survival rate was 87%, and the 15-year actuarial cause- specific survival rate was 96%. The 15-year actuarial rate of freedom from distant metastases was 96%. There were 45 local recurrences in the treated breast, and the 15-year actuarial rate of local failure was 19%. The median time to local failure was 5.2 years (range, 1.4 to 16.8). A number of clinical and pathologic parameters were evaluated for correlation with local failure, and none were predictive for local failure (all P ≥ .15). Conclusion: The results from the present study demonstrate rates of overall survival, cause-specific survival, and freedom from distant metastases following the treatment of DCIS of the breast using breast-conserving surgery and definitive breast irradiation. These results support the use of breast- conserving surgery and definitive breast irradiation for the treatment of DCIS of the breast.
AB - Purpose: To determine the 15-year outcome for women with ductal carcinoma in situ (DCIS, intraductal carcinoma) of the breast treated with breast- conserving surgery followed by definitive breast irradiation. Patients and Methods: An analysis was performed of 270 intraductal breast carcinomas in 268 women from 10 institutions in Europe and the United States. In all patients, breast-conserving surgery included complete gross excision of the primary tumor followed by definitive breast irradiation. When performed, pathologic axillary lymph node staging was node-negative (n = 86). The median follow-up time was 10.3 years (range, 0.9 to 26.8). Results: The 15-year actuarial overall survival rate was 87%, and the 15-year actuarial cause- specific survival rate was 96%. The 15-year actuarial rate of freedom from distant metastases was 96%. There were 45 local recurrences in the treated breast, and the 15-year actuarial rate of local failure was 19%. The median time to local failure was 5.2 years (range, 1.4 to 16.8). A number of clinical and pathologic parameters were evaluated for correlation with local failure, and none were predictive for local failure (all P ≥ .15). Conclusion: The results from the present study demonstrate rates of overall survival, cause-specific survival, and freedom from distant metastases following the treatment of DCIS of the breast using breast-conserving surgery and definitive breast irradiation. These results support the use of breast- conserving surgery and definitive breast irradiation for the treatment of DCIS of the breast.
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U2 - 10.1200/JCO.1996.14.3.754
DO - 10.1200/JCO.1996.14.3.754
M3 - Article
C2 - 8622021
AN - SCOPUS:9044224028
VL - 14
SP - 754
EP - 763
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
SN - 0732-183X
IS - 3
ER -