FIBROSpect II: A potential non invasive test to assess hepatic fibrosis

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Many forms of liver disease may ultimately lead to fibrosis of the liver, the most advanced state being cirrhosis. Cirrhosis is a morphologic disease that eventually results in a functional change of the liver. It is generally not accompanied by signs or symptoms early in its course, and is often diagnosed late when signs of liver failure become overt. Imaging studies may suggest cirrhosis, but only if there have been gross changes in the appearance of the liver, and this is often not the case. The only way to diagnose cirrhosis reliably has been through direct histologic examination of liver tissue. The drawback to histologic diagnosis has been the risks and discomfort associated with liver biopsy. Hesitation to perform the procedure also exists due to lack of experience of many practitioners and the low reimbursement rates for a procedure that is viewed as time consuming and potentially dangerous. The search for noninvasive modalities to assess fibrosis through biochemical and other means has begun. Several markers are currently under investigation, many of which are combined with clinical assessment and other biochemical parameters, to establish the presence of liver fibrosis. FIBROSpect II is an example of a commercially available assay that employs a combination of three markers to distinguish between no, minimal and advanced fibrosis.

Original languageEnglish (US)
Pages (from-to)593-597
Number of pages5
JournalExpert Review of Molecular Diagnostics
Volume4
Issue number5
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

Keywords

  • Cirrhosis
  • Fibrosis
  • FIBROSpect II
  • HCV
  • Noninvasive markers

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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