Fibrosis without fibroblast TGF-β receptors?

Manjeri A. Venkatachalam, Joel M. Weinberg

Research output: Contribution to journalComment/debate

4 Scopus citations

Abstract

A report by Neelisetty et al. suggests that TGFBR2 deletion from matrix-producing interstitial cells results in decreased transforming growth factor-β (TGF-β) signaling in the cells but does not decrease renal fibrosis after injury. Considered in the context of TGF-β signaling in different cell types involved in renal fibrosis and the existence of other ligands that may produce fibrosis, these findings are provocative, but owing to technical issues of recombination efficiency in inducible models of Cre-lox gene deletion, further studies are needed.

Original languageEnglish (US)
Pages (from-to)434-437
Number of pages4
JournalKidney international
Volume88
Issue number3
DOIs
StatePublished - Sep 3 2015

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ASJC Scopus subject areas

  • Nephrology

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