Fibrosis without fibroblast TGF-β receptors?

Manjeri A. Venkatachalam, Joel M. Weinberg

Research output: Contribution to journalComment/debatepeer-review

11 Scopus citations


A report by Neelisetty et al. suggests that TGFBR2 deletion from matrix-producing interstitial cells results in decreased transforming growth factor-β (TGF-β) signaling in the cells but does not decrease renal fibrosis after injury. Considered in the context of TGF-β signaling in different cell types involved in renal fibrosis and the existence of other ligands that may produce fibrosis, these findings are provocative, but owing to technical issues of recombination efficiency in inducible models of Cre-lox gene deletion, further studies are needed.

Original languageEnglish (US)
Pages (from-to)434-437
Number of pages4
JournalKidney international
Issue number3
StatePublished - Sep 3 2015

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Fibrosis without fibroblast TGF-β receptors?'. Together they form a unique fingerprint.

Cite this