Fibromyalgia syndrome in need of effective treatments

Theoharis C. Theoharides, Irene Tsilioni, Lauren Arbetman, Smaro Panagiotidou, Julia M. Stewart, Rae M. Gleason, Irwin J. Russell

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Fibromyalgia syndrome (FMS) is a chronic, idiopathic condition of widespread musculoskeletal pain, affecting primarily women. It is clinically characterized by chronic, nonarticular pain and a heightened response to pressure along with sleep disturbances, fatigue, bowel and bladder abnormalities, and cognitive dysfunction. The diagnostic criteria have changed repeatedly, and there is neither a definitive pathogenesis nor reliable diagnostic or prognostic biomarkers. Clinical and laboratory studies have provided evidence of altered central pain pathways. Recent evidence suggests the involvement of neuroinflammation with stress peptides triggering the release of neurosenzitizing mediators. The management of FMS requires a multidimensional approach including patient education, behavioral therapy, exercise, and pain management. Here we review recent data on the pathogenesis and propose new directions for research and treatment.

Original languageEnglish (US)
Pages (from-to)255-263
Number of pages9
JournalJournal of Pharmacology and Experimental Therapeutics
Volume355
Issue number2
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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