Fibroblasts from longer-lived species of primates, rodents, bats, carnivores, and birds resist protein damage

Andrew M. Pickering, Marcus Lehr, William J. Kohler, Melissa L. Han, Richard A. Miller

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Species differ greatly in their rates of aging. Among mammalian species life span ranges from 2 to over 60 years. Here, we test the hypothesis that skin-derived fibroblasts from long-lived species of animals differ from those of short-lived animals in their defenses against protein damage. In parallel studies of rodents, nonhuman primates, birds, and species from the Laurasiatheria superorder (bats, carnivores, shrews, and ungulates), we find associations between species longevity and resistance of proteins to oxidative stress after exposure to H2O2 or paraquat. In addition, baseline levels of protein carbonyl appear to be higher in cells from shorter-lived mammals compared with longer-lived mammals. Thus, resistance to protein oxidation is associated with species maximal life span in independent clades of mammals, suggesting that this cellular property may be required for evolution of longevity. Evaluation of the properties of primary fibroblast cell lines can provide insights into the factors that regulate the pace of aging across species of mammals.

Original languageEnglish (US)
Pages (from-to)791-799
Number of pages9
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume70
Issue number7
DOIs
StatePublished - Jan 11 2014

Keywords

  • Aging
  • Comparative biology
  • Oxidative stress

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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