Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK

Najoua Elbourkadi, Steven N. Austad, Richard A. Miller

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Summary: Fibroblasts from long-lived mutant mice show diminished phosphorylation of the stress-activated protein kinases ERK1/2 after exposure to peroxide, cadmium, or paraquat. We have now evaluated the kinetics of ERK phosphorylation in fibroblasts from long-lived and short-lived species of mammals and birds in response to stress by cadmium or hydrogen peroxide. Fibroblasts from the shorter-lived species of rodents and birds showed rapid induction of ERK phosphorylation, with a decline to basal level within 60 min. In contrast, cells from longer-lived species showed slower and more prolonged activation of ERK phosphorylation. These results suggest that fibroblasts from long-lived species may be less susceptible to the early phases of damage from cadmium or peroxide and suggest that altered kinetics of ERK activity may contribute to their stress resistance properties.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalAging cell
Volume13
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Birds
  • Evolution
  • Life span
  • Longevity regulation
  • Mammals
  • Oxidative stress
  • Signalling

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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