Fibrinolysis resistance after liver transplant as a predictor of early infection

Ivan E. Rodriguez, Dor Yoeli, Tanner Ferrell, Jessie G. Jiang, Ronald Truong, Trevor L. Nydam, Megan A. Adams, J. Michael Cullen, Elizabeth A. Pomfret, Hunter B. Moore

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Infection is a leading cause of morbidity in liver transplant (LT). Considering that the fibrinolytic system is altered in sepsis, we investigated the relationship between fibrinolysis resistance (FR) and post-transplant infection. Methods: Fibrinolysis was quantified using thrombelastography (TEG) with the addition of tPA to quantify FR. FR was defined as LY30 = 0% and stratified as transient if present on POD1 or POD5 (tFR), persistent (pFR) if present on both, or no FR (nFR) if absent. Results: 180 LT recipients were prospectively enrolled. 52 (29%) recipients developed infection. 72 had tFR; 37 had pFR; and 71 had nFR. Recipients with pFR had significantly greater incidence of infections (51% vs. 26% tFR vs. 20% nFR, p = 0.002). pFR was independently associated with increased odds of post-transplant infection (adjusted OR 3.39, p = 0.009). Conclusions: Persistent fibrinolysis resistance is associated with increased risk of post-transplant infection.

Original languageEnglish (US)
Pages (from-to)1455-1459
Number of pages5
JournalAmerican journal of surgery
Issue number6
StatePublished - Dec 2022
Externally publishedYes


  • Fibrinolysis resistance
  • Infection
  • Liver transplant
  • Plasminogen activator inhibitor 1 (PAI-1)
  • Thrombelastography (TEG)

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Fibrinolysis resistance after liver transplant as a predictor of early infection'. Together they form a unique fingerprint.

Cite this