Fibrinogen: Structure, function, and surface interactions

C. Fuss; J. C. Palmaz; E. A. Sprague

doi:10.1016/S1051-0443(07)61437-7

Fibrinogen: Structure, function, and surface interactions

C. Fuss, J. C. Palmaz, E. A. Sprague

Research output: Contribution to journal › Review article › peer-review

122 Scopus citations

Abstract

Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α₁₁₆,β₃ integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.

Original language	English (US)
Pages (from-to)	677-682
Number of pages	6
Journal	Journal of Vascular and Interventional Radiology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/S1051-0443(07)61437-7
State	Published - 2001

Keywords

Anticoagulant
Fibrinogen

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/S1051-0443(07)61437-7

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AU - Palmaz, J. C.

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N2 - Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α116,β3 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.

AB - Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α116,β3 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.

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Fibrinogen: Structure, function, and surface interactions

Abstract

Keywords

ASJC Scopus subject areas

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