Abstract
Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet α116,β3 integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.
Original language | English (US) |
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Pages (from-to) | 677-682 |
Number of pages | 6 |
Journal | Journal of Vascular and Interventional Radiology |
Volume | 12 |
Issue number | 6 |
DOIs | |
State | Published - 2001 |
Keywords
- Anticoagulant
- Fibrinogen
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine