Fibrin sealant in vascular surgery: A review

Paula K Shireman, Howard P. Greisler

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Fibrin sealant (FS) is a mixture of concentrated fibrinogen and thrombin that creates a fibrin matrix that is slowly degraded by the body's fibrinolytic system. FS is currently being used in the clinical arena for many applications. Perhaps the most relevant indication for vascular surgeons concentrates on FS's hemostatic properties. Current research in many centers is investigating FS's capability to incorporate drugs and cytokines into the fibrin matrix for slow release as a drug delivery system for future clinical use. This review will focus on three main uses of FS: as an anastomotic sealant, as an antibiotic coating, and as an agent for endothelialization of grafts.

Original languageEnglish (US)
Pages (from-to)117-132
Number of pages16
JournalJournal of Long-Term Effects of Medical Implants
Volume8
Issue number2
StatePublished - 1998
Externally publishedYes

Fingerprint

Fibrin Tissue Adhesive
Sealants
Surgery
Blood Vessels
Fibrin
Hemostatics
Drug Delivery Systems
Thrombin
Fibrinogen
Antibiotics
Grafts
Cytokines
Anti-Bacterial Agents
Transplants
Research
Pharmaceutical Preparations
Coatings

Keywords

  • Acidic FGF
  • Endothelial cells
  • Fibrin sealant
  • Fibrin tissue adhesive

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Orthopedics and Sports Medicine
  • Pathology and Forensic Medicine

Cite this

Fibrin sealant in vascular surgery : A review. / Shireman, Paula K; Greisler, Howard P.

In: Journal of Long-Term Effects of Medical Implants, Vol. 8, No. 2, 1998, p. 117-132.

Research output: Contribution to journalArticle

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