Abstract
Fibrin sealant (FS) is a mixture of concentrated fibrinogen and thrombin that creates a fibrin matrix that is slowly degraded by the body's fibrinolytic system. FS is currently being used in the clinical arena for many applications. Perhaps the most relevant indication for vascular surgeons concentrates on FS's hemostatic properties. Current research in many centers is investigating FS's capability to incorporate drugs and cytokines into the fibrin matrix for slow release as a drug delivery system for future clinical use. This review will focus on three main uses of FS: as an anastomotic sealant, as an antibiotic coating, and as an agent for endothelialization of grafts.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-132 |
| Number of pages | 16 |
| Journal | Journal of Long-Term Effects of Medical Implants |
| Volume | 8 |
| Issue number | 2 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Acidic FGF
- Endothelial cells
- Fibrin sealant
- Fibrin tissue adhesive
ASJC Scopus subject areas
- Biomedical Engineering
- Medicine (miscellaneous)
- Orthopedics and Sports Medicine
- Pathology and Forensic Medicine
Cite this
Fibrin sealant in vascular surgery : A review. / Shireman, Paula K; Greisler, Howard P.
In: Journal of Long-Term Effects of Medical Implants, Vol. 8, No. 2, 1998, p. 117-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fibrin sealant in vascular surgery
T2 - A review
AU - Shireman, Paula K
AU - Greisler, Howard P.
PY - 1998
Y1 - 1998
N2 - Fibrin sealant (FS) is a mixture of concentrated fibrinogen and thrombin that creates a fibrin matrix that is slowly degraded by the body's fibrinolytic system. FS is currently being used in the clinical arena for many applications. Perhaps the most relevant indication for vascular surgeons concentrates on FS's hemostatic properties. Current research in many centers is investigating FS's capability to incorporate drugs and cytokines into the fibrin matrix for slow release as a drug delivery system for future clinical use. This review will focus on three main uses of FS: as an anastomotic sealant, as an antibiotic coating, and as an agent for endothelialization of grafts.
AB - Fibrin sealant (FS) is a mixture of concentrated fibrinogen and thrombin that creates a fibrin matrix that is slowly degraded by the body's fibrinolytic system. FS is currently being used in the clinical arena for many applications. Perhaps the most relevant indication for vascular surgeons concentrates on FS's hemostatic properties. Current research in many centers is investigating FS's capability to incorporate drugs and cytokines into the fibrin matrix for slow release as a drug delivery system for future clinical use. This review will focus on three main uses of FS: as an anastomotic sealant, as an antibiotic coating, and as an agent for endothelialization of grafts.
KW - Acidic FGF
KW - Endothelial cells
KW - Fibrin sealant
KW - Fibrin tissue adhesive
UR - http://www.scopus.com/inward/record.url?scp=0031843045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031843045&partnerID=8YFLogxK
M3 - Article
C2 - 10181371
AN - SCOPUS:0031843045
VL - 8
SP - 117
EP - 132
JO - Journal of Long-Term Effects of Medical Implants
JF - Journal of Long-Term Effects of Medical Implants
SN - 1050-6934
IS - 2
ER -