Fibrin sealant in vascular surgery: A review

Paula K. Shireman, Howard P. Greisler

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Fibrin sealant (FS) is a mixture of concentrated fibrinogen and thrombin that creates a fibrin matrix that is slowly degraded by the body's fibrinolytic system. FS is currently being used in the clinical arena for many applications. Perhaps the most relevant indication for vascular surgeons concentrates on FS's hemostatic properties. Current research in many centers is investigating FS's capability to incorporate drugs and cytokines into the fibrin matrix for slow release as a drug delivery system for future clinical use. This review will focus on three main uses of FS: as an anastomotic sealant, as an antibiotic coating, and as an agent for endothelialization of grafts.

Original languageEnglish (US)
Pages (from-to)117-132
Number of pages16
JournalJournal of Long-Term Effects of Medical Implants
Issue number2
StatePublished - 1998
Externally publishedYes


  • Acidic FGF
  • Endothelial cells
  • Fibrin sealant
  • Fibrin tissue adhesive

ASJC Scopus subject areas

  • Biomedical Engineering
  • Dentistry(all)


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