Fibrin ring granulomas in Rickettsia typhi infection

Marcos Restrepo, E. Martin Vasquez, Carolina Echeverri, Kristin Fiebelkorn, Gregory M Anstead

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We describe a 71-year-old man hospitalized for fever and productive cough. Laboratory investigation showed anemia, thrombocytopenia, elevated transaminases, hyponatremia, and hypoalbuminemia. Computerized tomography of the abdomen, thorax, and sinuses, echocardiography, and a gallium scan did not reveal the source of the fever. The patient remained febrile despite courses of piperacillin-tazobactam/azithromycin and ceftriaxone/vancomycin. A bone marrow biopsy showed fibrin ring granulomas, and 2 rickettsial serologic panels were positive for Rickettsia typhi infection and negative for Q fever. The patient was given doxycycline, and the fever resolved within 48 h. We propose that fibrin ring granulomas also occur in murine typhus.

Original languageEnglish (US)
Pages (from-to)322-325
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume66
Issue number3
DOIs
StatePublished - Mar 2010

Fingerprint

Rickettsia typhi
Rickettsia Infections
Granuloma
Fibrin
Fever
Endemic Flea-Borne Typhus
Q Fever
Hypoalbuminemia
Gallium
Azithromycin
Ceftriaxone
Hyponatremia
Doxycycline
Vancomycin
Transaminases
Cough
Thrombocytopenia
Abdomen
Echocardiography
Anemia

Keywords

  • Fever of unknown origin
  • Fibrin ring granuloma
  • Murine typhus
  • Rickettsia typhi

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Fibrin ring granulomas in Rickettsia typhi infection. / Restrepo, Marcos; Vasquez, E. Martin; Echeverri, Carolina; Fiebelkorn, Kristin; Anstead, Gregory M.

In: Diagnostic Microbiology and Infectious Disease, Vol. 66, No. 3, 03.2010, p. 322-325.

Research output: Contribution to journalArticle

Restrepo, Marcos ; Vasquez, E. Martin ; Echeverri, Carolina ; Fiebelkorn, Kristin ; Anstead, Gregory M. / Fibrin ring granulomas in Rickettsia typhi infection. In: Diagnostic Microbiology and Infectious Disease. 2010 ; Vol. 66, No. 3. pp. 322-325.
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