Fibrin-Associated Diffuse Large B Cell Lymphoma Found on Revision Arthroplasty of the Knee

Jordan Hall, Craig Kampfer, Ned Williams, Michael Osswald, Bradie Bishop, Misty Hall, Joseph Alderete

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Fibrin-associated diffuse large B cell lymphoma (FA-DLBCL) is a rare Epstein-Barr viruspositive B cell lymphoma that is nonmass-forming, does not directly produce symptoms, and is incidentally discovered on histological examination of tissues excised for other reasons. Despite overlap in morphologic and immunophenotypic features with aggressive B cell neoplasms, FA-DLBCL shows an excellent clinical outcome, even with surgical excision alone. We report an extremely rare occurrence of FA-DLBCL found in association with a metallic implant on revision arthroplasty of the knee. This report also illustrates the need for an integrated multidisciplinary approach for accurate diagnosis and avoidance of overtreatment.

Original languageEnglish (US)
Pages (from-to)708-713
Number of pages6
JournalSouthern medical journal
Volume114
Issue number11
DOIs
StatePublished - Nov 1 2021
Externally publishedYes

Keywords

  • fibrin-associated (Epstein-Barr virus-positive) diffuse large B cell lymphoma (FA-DLBCL)
  • foreign body
  • multidisciplinary approach
  • non-Hodgkin lymphoma
  • orthopedic metallic implant

ASJC Scopus subject areas

  • General Medicine

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