Fhit is a physiological target of the protein kinase Src

Yuri Pekarsky, Preston N. Garrison, Alexey Palamarchuk, Nicola Zanesi, Rami I. Aqeilan, Kay Huebner, Larry D. Barnes, Carlo M. Croce

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The FHIT gene is a tumor suppressor that is frequently inactivated by genomic alterations at chromosomal region 3p14.2. In the last few years, a considerable amount of data describing inactivation of FHIT in a variety of human malignancies and demonstrating the tumor suppressor potential of Fhit have been reported. Despite the demonstration that FHIT functions as a tumor suppressor, the pathway through which Fhit induces apoptosis and inhibits growth of cancer cells is not known. Our data demonstrate that Fhit is a target of tyrosine phosphorylation by the Src protein kinase. We show that Src phosphorylates Y114 of Fhit in vitro and in vivo, providing insight into a biochemical pathway involved in Fhit signaling.

Original languageEnglish (US)
Pages (from-to)3775-3779
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number11
DOIs
StatePublished - Mar 16 2004

ASJC Scopus subject areas

  • General

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