Fetal brain during a binge drinking episode: A dynamic susceptibility contrast MRI fetal brain perfusion study

Peter Kochunov; Carlos Castro; Michael D Davis; Donald Dudley; Hsiao Ying Wey; David Purdy; Peter T. Fox; Calvin Simerly; Gerald Schatten

doi:10.1097/WNR.0b013e32833b5047

Fetal brain during a binge drinking episode: A dynamic susceptibility contrast MRI fetal brain perfusion study

Peter Kochunov, Carlos Castro, Michael D Davis, Donald Dudley, Hsiao Ying Wey, David Purdy, Peter T. Fox, Calvin Simerly, Gerald Schatten

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We assessed the effects of a single episode of maternal alcohol intoxication on fetal brain blood perfusion in three pregnant dams (baboons) at the 24th week of pregnancy using dynamic susceptibility contrast magnetic resonance imaging. After the oral administration of alcohol, there was a four-fold increase in the peak contrast concentrations in the fetal brain. In addition, we observed a two- to three-fold increase in the contrast uptake and washout rates in the fetal brain. The underlying mechanisms of these changes are unknown, but we hypothesized that these could include the alcohol-mediated changes in placental permeability and fetal cerebral blood flow. Our findings indicate that alcohol intoxication produces profound changes, which may detrimentally influence neurodevelopmental processes in the brain.

Original language	English (US)
Pages (from-to)	716-721
Number of pages	6
Journal	NeuroReport
Volume	21
Issue number	10
DOIs	https://doi.org/10.1097/WNR.0b013e32833b5047
State	Published - Jul 14 2010

Keywords

Brain imaging
Brain perfusion
Cerebral blood flow
Fetal alcohol syndrome
In utero
MRI
Placental permeability

ASJC Scopus subject areas

General Neuroscience

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10.1097/WNR.0b013e32833b5047

Cite this

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title = "Fetal brain during a binge drinking episode: A dynamic susceptibility contrast MRI fetal brain perfusion study",

abstract = "We assessed the effects of a single episode of maternal alcohol intoxication on fetal brain blood perfusion in three pregnant dams (baboons) at the 24th week of pregnancy using dynamic susceptibility contrast magnetic resonance imaging. After the oral administration of alcohol, there was a four-fold increase in the peak contrast concentrations in the fetal brain. In addition, we observed a two- to three-fold increase in the contrast uptake and washout rates in the fetal brain. The underlying mechanisms of these changes are unknown, but we hypothesized that these could include the alcohol-mediated changes in placental permeability and fetal cerebral blood flow. Our findings indicate that alcohol intoxication produces profound changes, which may detrimentally influence neurodevelopmental processes in the brain.",

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AU - Castro, Carlos

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AU - Dudley, Donald

AU - Wey, Hsiao Ying

AU - Purdy, David

AU - Fox, Peter T.

AU - Simerly, Calvin

AU - Schatten, Gerald

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KW - Cerebral blood flow

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Fetal brain during a binge drinking episode: A dynamic susceptibility contrast MRI fetal brain perfusion study

Abstract

Keywords

ASJC Scopus subject areas

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