Fetal brain during a binge drinking episode: A dynamic susceptibility contrast MRI fetal brain perfusion study

Peter Kochunov, Carlos Castro, Duff M. Davis, Donald Dudley, Hsiao Ying Wey, David Purdy, Peter T. Fox, Calvin Simerly, Gerald Schatten

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We assessed the effects of a single episode of maternal alcohol intoxication on fetal brain blood perfusion in three pregnant dams (baboons) at the 24th week of pregnancy using dynamic susceptibility contrast magnetic resonance imaging. After the oral administration of alcohol, there was a four-fold increase in the peak contrast concentrations in the fetal brain. In addition, we observed a two- to three-fold increase in the contrast uptake and washout rates in the fetal brain. The underlying mechanisms of these changes are unknown, but we hypothesized that these could include the alcohol-mediated changes in placental permeability and fetal cerebral blood flow. Our findings indicate that alcohol intoxication produces profound changes, which may detrimentally influence neurodevelopmental processes in the brain.

Original languageEnglish (US)
Pages (from-to)716-721
Number of pages6
JournalNeuroReport
Volume21
Issue number10
DOIs
StatePublished - Jul 14 2010

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Keywords

  • Brain imaging
  • Brain perfusion
  • Cerebral blood flow
  • Fetal alcohol syndrome
  • In utero
  • MRI
  • Placental permeability

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kochunov, P., Castro, C., Davis, D. M., Dudley, D., Wey, H. Y., Purdy, D., Fox, P. T., Simerly, C., & Schatten, G. (2010). Fetal brain during a binge drinking episode: A dynamic susceptibility contrast MRI fetal brain perfusion study. NeuroReport, 21(10), 716-721. https://doi.org/10.1097/WNR.0b013e32833b5047