Ferulic Acid Alleviates Lipid Peroxidation in Diabetic Rats

M. Sri Balasubashini, R. Rukkumani, P. Viswanathan, Venugopal P. Menon

Research output: Contribution to journalArticlepeer-review

213 Scopus citations


Diabetes mellitus is a metabolic disorder associated with increased formation of free radicals. The objective of our study was to determine whether ferulic acid (FA), a phenolic acid, has any role to play in diabetes induced free radical formation. Diabetes was induced with streptozotocin. The levels of blood glucose, thiobarbituric acid reactive substances (TBARS), hydroperoxides and free fatty acids (FFA) increased in the liver of diabetic animals. The activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) decreased in the liver. Histopathology of pancreas also shows shrunken islets. Supplementation of FA to the diabetic rats resulted in a decrease in the levels of glucose, TBARS, hydroperoxides, FFA and an increase in reduced glutathione (GSH). FA also resulted in increased activities of SOD, CAT, GPx and expansion of pancreatic islets. The effect was much pronounced with lower dose treatment. Thus our study shows that administration of ferulic acid helps in enhancing the antioxidant capacity of these diabetic animals by neutralizing the free radicals formed thereby reducing the intensity of diabetes.

Original languageEnglish (US)
Pages (from-to)310-314
Number of pages5
JournalPhytotherapy Research
Issue number4
StatePublished - Apr 2004
Externally publishedYes


  • Antioxidants
  • Blood glucose
  • Diabetes
  • Ferulic acid
  • Lipid peroxidation

ASJC Scopus subject areas

  • Pharmacology


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