Water-soluble contrast materials have been employed in diagnostic radiology since 1931, but because of irritative effects their use in myelography has been limited. Since 1963, meglumine iothalamate (conray) has been employed for myelography because of its relatively low toxicity, but myoclonic spasms have been associated with use of this agent at a frequency of 8 to 19%. Therefore, meglumine iocarmate (Dimeray), a synthesized dimer of meglumine iothalamate, was developed in an effort to decrease these irritative effects. However, the intensity of the spasmodic muscle contractions sometimes associated with the use of either of these agents has been sufficient to cause fractures, including fractures of the ilium and pubis. We are recording another instance of a myoclonic seizure following use of meglumine iocarmate which resulted in bilateral fracture of the femoral neck in a young man who had no skeletal abnormality.
ASJC Scopus subject areas
- Orthopedics and Sports Medicine