Female reproductive health in cystic fibrosis

Kara S. Hughan, Tanicia Daley, Maria Socorro Rayas, Andrea Kelly, Andrea Roe

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Women with cystic fibrosis (CF) are living longer and healthier lives, and opportunities for childbearing are increasingly promising. However, this population can also face sexual and reproductive health concerns, including menstrual irregularities, unplanned pregnancies, infertility and pregnancy complications. Additionally, more women are entering menopause and are at risk for the consequences of estrogen deficiency. The exact mechanisms involved in female reproductive health conditions in CF are not clearly understood, but are thought to include cystic fibrosis transmembrane regulator (CFTR)-mediated abnormalities, changes in female sex hormones, and other CF health-related factors. In the era of CFTR modulator therapy, new data are necessary to understand the impact of CFTR modulation on contraceptive effectiveness, fertility, and pregnancy outcomes to help guide future clinical care. This article reviews the current scientific knowledge of major reproductive health issues for women with CF.

Original languageEnglish (US)
Pages (from-to)S95-S104
JournalJournal of Cystic Fibrosis
Volume18
DOIs
StatePublished - Oct 2019

Keywords

  • Amenorrhea
  • Contraception
  • Cystic fibrosis
  • Fertility
  • Menstruation
  • Pregnancy
  • Reproductive health

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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