Although amyl nitrite inhalation (ANI) antedates current short acting vasodilators as a clinically useful pharcologic stressor, few clinicians are aware of the subtle hemonamic actions of this agent. This study examined transients left and right heart hemodynamics after ANI in seven men ages 44 ± 7 years) undergoing elective cardiac catheterization. ‐fidelity central aortic (AoP), left ventricular (LVP), pulonary artery (PAP), right ventricular (RVP), and right atrial (PAP) pressures were simultaneously recorded from left and right heart multisensor catheters. As expected, ANI caused an fall in Ao pressure (27%; p<0.01) and reflex (p<0.001). Little change was noted in PAP, RVP, RAP, or end‐diastolic pressures or the time constant of LV isovolnetric relaxation (tau). LV ejection time decreased 23 ± 10 (p<0.05) and RV ejection time did not change. Baroreflex was similar during pressure fall and recovery (6.4 ± vs. 6.1 ± 3.6 ms/mmHg), however hysteresis (p<0.05) was. Aortic pressure waveforms also changed following ANI. Changes were determined to be in part a consequence of the atanuation and delay in arterial wave reflections. This study the understanding of the complex nature of the hemodynamic response associated with ANI.
- amyl nitrite
- arterial reflections
- blood pressure
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine