Feasibility study of evaluation of therapeutic effect for sleep apnea syndrome using mental healthiness evaluated from voice

Mitsuteru Nakamura, Shuji Shinohara, Yasuhiro Omiya, Shunji Mitsuyoshi, Masakazu Higuchi, Naoki Hagiwara, Takeshi Takano, Hirosuke Danno, Shun Ichi Tanaka, Shinichi Tokuno

Research output: Contribution to journalConference articlepeer-review


Dealing with sleep apnea syndrome (SAS) is important because of its social burden, however current standard diagnosis requires a costly examination (polysomnography, PSG). Therefore, strong demand for easy screening methods for SAS exists. There is also a need for evaluation of therapeutic effect by continuous positive airway pressure (CPAP). Because CPAP requires adjustment of parameters (titration), or CPAP used inadequately will not improve a patient’s symptom. Considering quality of life, evaluation of therapeutic effect requires monitoring of mental and physical conditions in daytime. We already reported that mental healthiness evaluated from voice, called “vitality,” showed some correlation with severity of SAS. In this study we examined feasibility of vitality as an index of therapeutic effect by CPAP. We recorded voices from subjects when they were examined by PSG for first diagnosis and titration, before and after each examination. Then we evaluated vitality of the subjects at the recording. The subjects were categorized into two groups; subjects of a group started using CPAP after titration, and subjects of another group started using CPAP before titration. As results, direction of change in vitality in the former group varied by subjects at titration, while vitality in the latter group showed tendency of improvement. Within the latter group, the change in vitality tends to get larger as usage rate of CPAP before titration is higher. This result suggests that vitality has a potential for an easy method to evaluate therapeutic effect for SAS, and that diligence of CPAP usage is important for effective treatment.

Original languageEnglish (US)
Pages (from-to)897-900
Number of pages4
JournalIFMBE Proceedings
Issue number2
StatePublished - 2018
Externally publishedYes
EventWorld Congress on Medical Physics and Biomedical Engineering, WC 2018 - Prague, Czech Republic
Duration: Jun 3 2018Jun 8 2018


  • Continuous positive airway pressure
  • Mental healthiness
  • Sleep apnea syndrome
  • Voice analysis of pathophysiology

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering


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