Fate of allogeneic skin transplantations in a marsupial (Monodelphis domestica)

W. H. Stone, G. S. Manis, E. S. Hoffman, D. G. Saphire, G. B. Hubbard, J. L. VandeBerg

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Previously we reported that the South American gray short-tailed opossum, Monodelphis domestica, had an MHC class-I locus similar to that of eutherian species. In addition to the detection of lymphocyte antigens by cytotoxic antisera, we concluded that this marsupial rejected allogeneic skin grafts, as would be expected of animals with MHC class-I polymorphism. However, this conclusion was based on a limited number of skin transplants that were assayed for only a short period. Here we report the results of 22 reciprocal skin grafts made between individuals of known genetic relationships. On the basis of gross inspection of the grafts and histologic examination, we found that the average time of the onset of graft rejection was about 19 days and that the average time for complete graft rejection was about 31 days. In general, it took longer for the onset of graft rejection among pairs of genetically related animals than among less related animals. These results indicate unequivocally that this marsupial species has a high degree of class-I polymorphism and rejects allogeneic skin transplants in a manner similar to but more slowly than eutherian mammals.

Original languageEnglish (US)
Pages (from-to)283-287
Number of pages5
JournalLaboratory Animal Science
Volume47
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Monodelphis
skin grafting
Monodelphis domestica
Marsupialia
Skin Transplantation
Homologous Transplantation
Metatheria
skin (animal)
graft rejection
Grafts
Skin
Transplants
Graft Rejection
Animals
genetic polymorphism
lymphocyte antigens
Polymorphism
animals
opossums
genetic relationships

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Stone, W. H., Manis, G. S., Hoffman, E. S., Saphire, D. G., Hubbard, G. B., & VandeBerg, J. L. (1997). Fate of allogeneic skin transplantations in a marsupial (Monodelphis domestica). Laboratory Animal Science, 47(3), 283-287.

Fate of allogeneic skin transplantations in a marsupial (Monodelphis domestica). / Stone, W. H.; Manis, G. S.; Hoffman, E. S.; Saphire, D. G.; Hubbard, G. B.; VandeBerg, J. L.

In: Laboratory Animal Science, Vol. 47, No. 3, 1997, p. 283-287.

Research output: Contribution to journalArticle

Stone, WH, Manis, GS, Hoffman, ES, Saphire, DG, Hubbard, GB & VandeBerg, JL 1997, 'Fate of allogeneic skin transplantations in a marsupial (Monodelphis domestica)', Laboratory Animal Science, vol. 47, no. 3, pp. 283-287.
Stone WH, Manis GS, Hoffman ES, Saphire DG, Hubbard GB, VandeBerg JL. Fate of allogeneic skin transplantations in a marsupial (Monodelphis domestica). Laboratory Animal Science. 1997;47(3):283-287.
Stone, W. H. ; Manis, G. S. ; Hoffman, E. S. ; Saphire, D. G. ; Hubbard, G. B. ; VandeBerg, J. L. / Fate of allogeneic skin transplantations in a marsupial (Monodelphis domestica). In: Laboratory Animal Science. 1997 ; Vol. 47, No. 3. pp. 283-287.
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