Fat-predominant mixed epithelial stromal tumor (MEST): Report of a unique case mimicking angiomyolipoma

Anthony N. Sireci, Ronald Rodriguez, Sharon L. Swierczynski, George J. Netto, Pedram Argani

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A unique case of a mixed epithelial stromal tumor (MEST) that was predominantly composed of adipose tissue is reported here. Radiographically and grossly, the lesion was thought to be an angiomyolipoma, based upon its fatty appearance. Microscopically, the lesion was predominantly composed of mature adipose tissue but also contained clusters of bland tubules surrounded by smooth muscle bundles and collagen. By immunohistochemistry, the stroma labeled diffusely for estrogen and progesterone receptors, while the muscle bundles labeled for desmin. Melanocytic markers HMB45 and Melan A, typically positive in angiomyolipoma, were nonreactive. This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalInternational Journal of Surgical Pathology
Issue number1
StatePublished - Jan 2008
Externally publishedYes


  • Angiomyolipoma
  • Fat
  • Kidney
  • Mixed epithelial stromal tumor

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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