TY - JOUR
T1 - Fat-predominant mixed epithelial stromal tumor (MEST)
T2 - Report of a unique case mimicking angiomyolipoma
AU - Sireci, Anthony N.
AU - Rodriguez, Ronald
AU - Swierczynski, Sharon L.
AU - Netto, George J.
AU - Argani, Pedram
PY - 2008/1
Y1 - 2008/1
N2 - A unique case of a mixed epithelial stromal tumor (MEST) that was predominantly composed of adipose tissue is reported here. Radiographically and grossly, the lesion was thought to be an angiomyolipoma, based upon its fatty appearance. Microscopically, the lesion was predominantly composed of mature adipose tissue but also contained clusters of bland tubules surrounded by smooth muscle bundles and collagen. By immunohistochemistry, the stroma labeled diffusely for estrogen and progesterone receptors, while the muscle bundles labeled for desmin. Melanocytic markers HMB45 and Melan A, typically positive in angiomyolipoma, were nonreactive. This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma.
AB - A unique case of a mixed epithelial stromal tumor (MEST) that was predominantly composed of adipose tissue is reported here. Radiographically and grossly, the lesion was thought to be an angiomyolipoma, based upon its fatty appearance. Microscopically, the lesion was predominantly composed of mature adipose tissue but also contained clusters of bland tubules surrounded by smooth muscle bundles and collagen. By immunohistochemistry, the stroma labeled diffusely for estrogen and progesterone receptors, while the muscle bundles labeled for desmin. Melanocytic markers HMB45 and Melan A, typically positive in angiomyolipoma, were nonreactive. This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma.
KW - Angiomyolipoma
KW - Fat
KW - Kidney
KW - Mixed epithelial stromal tumor
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U2 - 10.1177/1066896907304523
DO - 10.1177/1066896907304523
M3 - Article
C2 - 18203791
AN - SCOPUS:37549051793
SN - 1066-8969
VL - 16
SP - 73
EP - 77
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 1
ER -