Fat-predominant mixed epithelial stromal tumor (MEST): Report of a unique case mimicking angiomyolipoma

Anthony N. Sireci, Ronald Rodriguez, Sharon L. Swierczynski, George J. Netto, Pedram Argani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A unique case of a mixed epithelial stromal tumor (MEST) that was predominantly composed of adipose tissue is reported here. Radiographically and grossly, the lesion was thought to be an angiomyolipoma, based upon its fatty appearance. Microscopically, the lesion was predominantly composed of mature adipose tissue but also contained clusters of bland tubules surrounded by smooth muscle bundles and collagen. By immunohistochemistry, the stroma labeled diffusely for estrogen and progesterone receptors, while the muscle bundles labeled for desmin. Melanocytic markers HMB45 and Melan A, typically positive in angiomyolipoma, were nonreactive. This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalInternational Journal of Surgical Pathology
Volume16
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

Fingerprint

Angiomyolipoma
Fats
Adipose Tissue
MART-1 Antigen
Neoplasms
Desmin
Progesterone Receptors
Estrogen Receptors
Smooth Muscle
Collagen
Immunohistochemistry
Muscles

Keywords

  • Angiomyolipoma
  • Fat
  • Kidney
  • Mixed epithelial stromal tumor

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Fat-predominant mixed epithelial stromal tumor (MEST) : Report of a unique case mimicking angiomyolipoma. / Sireci, Anthony N.; Rodriguez, Ronald; Swierczynski, Sharon L.; Netto, George J.; Argani, Pedram.

In: International Journal of Surgical Pathology, Vol. 16, No. 1, 01.2008, p. 73-77.

Research output: Contribution to journalArticle

Sireci, Anthony N. ; Rodriguez, Ronald ; Swierczynski, Sharon L. ; Netto, George J. ; Argani, Pedram. / Fat-predominant mixed epithelial stromal tumor (MEST) : Report of a unique case mimicking angiomyolipoma. In: International Journal of Surgical Pathology. 2008 ; Vol. 16, No. 1. pp. 73-77.
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