Fast spin‐echo characteristics of visual stimulation‐induced signal changes in the human brain

Jia‐Hong ‐H Gao, Jinhu Xiong, Jinqi Li, Joseph Schiff, John Roby, Jack L. Lancaster, Peter T. Fox

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A fast spin‐echo (FSE) technique used in a conventional MR imaging scanner has been successfully developed for obtaining functional MR images with high spatial resolution and multiple slices. Our preliminary visual stimulation studies using the FSE technique show that the nuclear MR signal increases by 2.6% during activation in the primary visual cortex. These results provide evidence that the diffusion of tissue water molecules plays a key role in determining functional MR signal amplitude. Because the FSE functional MR imaging signal is extremely sensitive to microvascular (brain capillaries) hemodynamics, the FSE technique can be a powerful tool for studying the neuronal activity of the human brain.

Original languageEnglish (US)
Pages (from-to)709-714
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume5
Issue number6
DOIs
StatePublished - 1995

Keywords

  • Blood flow
  • Fast spin‐echo
  • Functional MR imaging
  • Tissue diffusion
  • Visual stimulation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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