Familial Studies

Genetic Inferences

Vincent P. Diego, Jack W. Kent, John Blangero

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Most human characteristics (including behavioral and neurocognitive phenotypes) are influenced to some extent by heritable genetic variation. The concept of heritability, which is a measure of the relative amount of observed phenotypic variance that is attributable to genes, has had a long and controversial history in human genetics. Inference about heritability obtained from familial relationships predated and informed the discovery of the cellular and biochemical mechanisms of inheritance. Our recent ability to obtain complete DNA sequence of individual genomes reveals the full extent of human genetic diversity, and allows for identification of empirical patterns of kinship when family structure is unknown. In this context, the tools of statistical genetics remain essential for quantifying, identifying, and interpreting causal relationships of genetic variation to traits of interest. This article reviews key concepts and controversies in statistical genetics and introduces recent advances in efficient inference from complex pedigrees.

Original languageEnglish (US)
Title of host publicationInternational Encyclopedia of the Social & Behavioral Sciences: Second Edition
PublisherElsevier Inc.
Pages715-724
Number of pages10
ISBN (Electronic)9780080970875
ISBN (Print)9780080970868
DOIs
StatePublished - Mar 26 2015
Externally publishedYes

Fingerprint

family structure
kinship
ability
history

Keywords

  • Additive genetic variance
  • Heritability
  • Rare sequence variants
  • Variance components

ASJC Scopus subject areas

  • Social Sciences(all)

Cite this

Diego, V. P., Kent, J. W., & Blangero, J. (2015). Familial Studies: Genetic Inferences. In International Encyclopedia of the Social & Behavioral Sciences: Second Edition (pp. 715-724). Elsevier Inc.. https://doi.org/10.1016/B978-0-08-097086-8.82029-2

Familial Studies : Genetic Inferences. / Diego, Vincent P.; Kent, Jack W.; Blangero, John.

International Encyclopedia of the Social & Behavioral Sciences: Second Edition. Elsevier Inc., 2015. p. 715-724.

Research output: Chapter in Book/Report/Conference proceedingChapter

Diego, VP, Kent, JW & Blangero, J 2015, Familial Studies: Genetic Inferences. in International Encyclopedia of the Social & Behavioral Sciences: Second Edition. Elsevier Inc., pp. 715-724. https://doi.org/10.1016/B978-0-08-097086-8.82029-2
Diego VP, Kent JW, Blangero J. Familial Studies: Genetic Inferences. In International Encyclopedia of the Social & Behavioral Sciences: Second Edition. Elsevier Inc. 2015. p. 715-724 https://doi.org/10.1016/B978-0-08-097086-8.82029-2
Diego, Vincent P. ; Kent, Jack W. ; Blangero, John. / Familial Studies : Genetic Inferences. International Encyclopedia of the Social & Behavioral Sciences: Second Edition. Elsevier Inc., 2015. pp. 715-724
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