False-positive interpretations in respiratory cytopathology: Exemplary cases and literature review

Maria Luisa C. Policarpio-Nicolas, Mark R. Wick

Research output: Contribution to journalArticle

24 Scopus citations


Pulmonary cytology has progressed over the past decades because of advancement in imaging studies and increased confidence of pathologists in cytomorphologic diagnosis. It has an overall sensitivity and specificity ranging from ∼60 to 96%. However, even with the most conscientious laboratories, false-positive diagnoses of malignancy do occur in respiratory specimens, potentially resulting in unnecessary treatment and morbidity. Selected respiratory cytopathology cases with false-positive diagnoses are presented here, along with a review of pertinent literature and a discussion of possible steps to minimize the problem being considered.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalDiagnostic Cytopathology
Issue number1
Publication statusPublished - Jan 1 2008



  • False-positive results
  • Respiratory cytology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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