Faithful after break-up: Suppression of chromosomal translocations

Sang Eun Lee, Kyungjae Myung

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Chromosome integrity in response to chemically or radiation-induced chromosome breaks and the perturbation of ongoing replication forks relies on multiple DNA repair mechanisms. However, repair of these lesions may lead to unwanted chromosome rearrangement if not properly executed or regulated. As these types of chromosomal alterations threaten the cell's and the organism's very own survival, multiple systems are developed to avoid or at least limit break-induced chromosomal rearrangements. In this review, we highlight cellular strategies for repressing DNA break-induced chromosomal translocations in multiple model systems including yeast, mouse, and human. These pathways select proper homologous templates or broken DNA ends for the faithful repair of DNA breaks to avoid undesirable chromosomal translocations.

Original languageEnglish (US)
Pages (from-to)3149-3160
Number of pages12
JournalCellular and Molecular Life Sciences
Volume66
Issue number19
DOIs
StatePublished - Oct 2009

Keywords

  • Chromosomal translocation
  • DNA repair
  • Double strand break
  • End joining
  • Homologous recombination

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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