Failure of pinealectomy to affect acute changes in plasma levels of luteinizing hormone and prolactin in ovariectomized rats following δ9-tetrahydrocannabinol administration

L. Y. Johnson; R. H. Asch; R. J. Reiter

Failure of pinealectomy to affect acute changes in plasma levels of luteinizing hormone and prolactin in ovariectomized rats following δ⁹-tetrahydrocannabinol administration

L. Y. Johnson, R. H. Asch, R. J. Reiter

Cell Systems & Anatomy

Research output: Contribution to journal › Article

Abstract

Δ⁹-Tetrahydrocannabinol (THC) (2.5 mg/kg BW) treatment acutely depressed plasma levels of luteinizing hormone and prolactin in cannulated rats ovariectomized five weeks earlier. Pinealectomy prior to castration did not eliminate or significantly modify these hormonal changes. Thus, these effects of THC do not appear to be mediated by the pineal gland or influenced by it under long photoperiodic conditions (14L:10D).

Original language	English (US)
Pages (from-to)	355-359
Number of pages	5
Journal	Substance and Alcohol Actions/Misuse
Volume	1
Issue number	4
State	Published - Dec 1 1980

ASJC Scopus subject areas

Medicine(all)

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Johnson, L. Y., Asch, R. H., & Reiter, R. J. (1980). Failure of pinealectomy to affect acute changes in plasma levels of luteinizing hormone and prolactin in ovariectomized rats following δ⁹-tetrahydrocannabinol administration. Substance and Alcohol Actions/Misuse, 1(4), 355-359.

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abstract = "Δ9-Tetrahydrocannabinol (THC) (2.5 mg/kg BW) treatment acutely depressed plasma levels of luteinizing hormone and prolactin in cannulated rats ovariectomized five weeks earlier. Pinealectomy prior to castration did not eliminate or significantly modify these hormonal changes. Thus, these effects of THC do not appear to be mediated by the pineal gland or influenced by it under long photoperiodic conditions (14L:10D).",

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N2 - Δ9-Tetrahydrocannabinol (THC) (2.5 mg/kg BW) treatment acutely depressed plasma levels of luteinizing hormone and prolactin in cannulated rats ovariectomized five weeks earlier. Pinealectomy prior to castration did not eliminate or significantly modify these hormonal changes. Thus, these effects of THC do not appear to be mediated by the pineal gland or influenced by it under long photoperiodic conditions (14L:10D).

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