Failure of Cytarabine in Varicella-Zoster Infections

Charles M. Davis, Jules V. Vandersarl, Charles A. Coltman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


In an effort to confirm the reported efficacy of cytarabine for the treatment of varicella-zoster (VZ), a double-blind study comparing cytarabine—150 mg/sq m of body surface for 36 hours—to dextrose in water was performed in cancer and immunosuppressed patients. One of the five cytarabine-treated patients and two of the three placebo-treated patients developed disseminated lesions. The acute phase and the time necessary for healing were the same in both groups. Until the natural course of VZ is documented in a large series of cancer patients, the benefit of medications such as cytarabine will remain in doubt.

Original languageEnglish (US)
Pages (from-to)122-123
Number of pages2
JournalJAMA: The Journal of the American Medical Association
Issue number1
StatePublished - Apr 2 1973
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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