Failed tubule recovery, AKI-CKD transition, and kidney disease progression

Manjeri A. Venkatachalam, Joel M. Weinberg, Wilhelm Kriz, Anil K. Bidani

Research output: Contribution to journalReview article

234 Scopus citations

Abstract

The transition of AKI to CKDhasmajor clinical significance. As reviewed here, recent studies show that a subpopulation of dedifferentiated, proliferating tubules recovering from AKI undergo pathologic growth arrest, fail to redifferentiate, and become atrophic. These abnormal tubules exhibit persistent, unregulated, and progressively increasing profibrotic signaling along multiple pathways. Paracrine products derived therefrom perturb normal interactions between peritubular capillary endothelium and pericyte-like fibroblasts, leading to myofibroblast transformation, proliferation, and fibrosis as well as capillary disintegration and rarefaction. Although signals from injured endothelium and inflammatory/immune cells also contribute, tubule injury alone is sufficient to produce the interstitial pathology required for fibrosis. Localized hypoxia produced by microvascular pathology may also prevent tubule recovery. However, fibrosis is not intrinsically progressive, and microvascular pathology develops strictly around damaged tubules; thus, additional deterioration of kidney structure after the transition of AKI to CKD requires new acute injury or other mechanisms of progression. Indeed, experiments using an acute-on-chronic injury model suggest that additional loss of parenchyma caused by failed repair of AKI in kidneys with prior renal mass reduction triggers hemodynamically mediated processes that damage glomeruli to cause progression. Continued investigation of these pathologic mechanisms should reveal options for preventing renal disease progression after AKI.

Original languageEnglish (US)
Pages (from-to)1765-1776
Number of pages12
JournalJournal of the American Society of Nephrology
Volume26
Issue number8
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Nephrology

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