Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans

Rector Arya, John Blangero, Ken Williams, Laura Almasy, Thomas D. Dyer, Robin J Leach, Peter O'Connell, Michael P. Stern, Ravindranath Duggirala

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Insulin resistance syndrome (IRS)-related phenotypes, such as hyperinsulinemia, obesity-related traits, impaired glucose tolerance, dyslipidemia, and hypertension, tend to cluster into factors. We attempted to identify loci influencing the factors of IRS-related phenotypes using phenotypic data from 261 nondiabetic subjects distributed across 27 low-income Mexican-American extended families. Principal component factor analyses were performed using eight IRS-related phenotypes: fasting glucose (FG), fasting specific insulin (FSI), BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), HDL cholesterol, In triglycerides (In TGs), and leptin (LEP). The factor analysis yielded three factors: factor 1 (BMI, LEP, and FSI), factor 2 (DBP and SBP), and factor 3 (HDL and In TG). We conducted multipoint variance components linkage analyses on these factors with the program SOLAR using a 10-15 cM map. We found significant evidence for linkage of factor 1 to two regions on chromosome 6 near markers D6S403 (logarithm of odds [LOD] = 4.2) and D6S264 (LOD = 4.9). We also found strong evidence for linkage of factor 3 to a genetic location on chromosome 7 between markers D7S479 and D7S471 (LOD = 3.2). In conclusion, we found substantial evidence for susceptibility loci on chromosomes 6 and 7 that appear to influence the factors representing the IRS-related phenotypes in Mexican-Americans.

Original languageEnglish (US)
Pages (from-to)841-847
Number of pages7
JournalDiabetes
Volume51
Issue number3
StatePublished - 2002

Fingerprint

Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7
Insulin Resistance
Blood Pressure
Phenotype
Statistical Factor Analysis
Fasting
Leptin
HDL3 Lipoprotein
Insulin
Glucose Intolerance
Hyperinsulinism
Dyslipidemias
Principal Component Analysis
HDL Cholesterol
Triglycerides
Obesity
Hypertension
Glucose

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans. / Arya, Rector; Blangero, John; Williams, Ken; Almasy, Laura; Dyer, Thomas D.; Leach, Robin J; O'Connell, Peter; Stern, Michael P.; Duggirala, Ravindranath.

In: Diabetes, Vol. 51, No. 3, 2002, p. 841-847.

Research output: Contribution to journalArticle

Arya, R, Blangero, J, Williams, K, Almasy, L, Dyer, TD, Leach, RJ, O'Connell, P, Stern, MP & Duggirala, R 2002, 'Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans', Diabetes, vol. 51, no. 3, pp. 841-847.
Arya, Rector ; Blangero, John ; Williams, Ken ; Almasy, Laura ; Dyer, Thomas D. ; Leach, Robin J ; O'Connell, Peter ; Stern, Michael P. ; Duggirala, Ravindranath. / Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans. In: Diabetes. 2002 ; Vol. 51, No. 3. pp. 841-847.
@article{1dc4487513a04d8d85cb98b51167354f,
title = "Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans",
abstract = "Insulin resistance syndrome (IRS)-related phenotypes, such as hyperinsulinemia, obesity-related traits, impaired glucose tolerance, dyslipidemia, and hypertension, tend to cluster into factors. We attempted to identify loci influencing the factors of IRS-related phenotypes using phenotypic data from 261 nondiabetic subjects distributed across 27 low-income Mexican-American extended families. Principal component factor analyses were performed using eight IRS-related phenotypes: fasting glucose (FG), fasting specific insulin (FSI), BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), HDL cholesterol, In triglycerides (In TGs), and leptin (LEP). The factor analysis yielded three factors: factor 1 (BMI, LEP, and FSI), factor 2 (DBP and SBP), and factor 3 (HDL and In TG). We conducted multipoint variance components linkage analyses on these factors with the program SOLAR using a 10-15 cM map. We found significant evidence for linkage of factor 1 to two regions on chromosome 6 near markers D6S403 (logarithm of odds [LOD] = 4.2) and D6S264 (LOD = 4.9). We also found strong evidence for linkage of factor 3 to a genetic location on chromosome 7 between markers D7S479 and D7S471 (LOD = 3.2). In conclusion, we found substantial evidence for susceptibility loci on chromosomes 6 and 7 that appear to influence the factors representing the IRS-related phenotypes in Mexican-Americans.",
author = "Rector Arya and John Blangero and Ken Williams and Laura Almasy and Dyer, {Thomas D.} and Leach, {Robin J} and Peter O'Connell and Stern, {Michael P.} and Ravindranath Duggirala",
year = "2002",
language = "English (US)",
volume = "51",
pages = "841--847",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "3",

}

TY - JOUR

T1 - Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans

AU - Arya, Rector

AU - Blangero, John

AU - Williams, Ken

AU - Almasy, Laura

AU - Dyer, Thomas D.

AU - Leach, Robin J

AU - O'Connell, Peter

AU - Stern, Michael P.

AU - Duggirala, Ravindranath

PY - 2002

Y1 - 2002

N2 - Insulin resistance syndrome (IRS)-related phenotypes, such as hyperinsulinemia, obesity-related traits, impaired glucose tolerance, dyslipidemia, and hypertension, tend to cluster into factors. We attempted to identify loci influencing the factors of IRS-related phenotypes using phenotypic data from 261 nondiabetic subjects distributed across 27 low-income Mexican-American extended families. Principal component factor analyses were performed using eight IRS-related phenotypes: fasting glucose (FG), fasting specific insulin (FSI), BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), HDL cholesterol, In triglycerides (In TGs), and leptin (LEP). The factor analysis yielded three factors: factor 1 (BMI, LEP, and FSI), factor 2 (DBP and SBP), and factor 3 (HDL and In TG). We conducted multipoint variance components linkage analyses on these factors with the program SOLAR using a 10-15 cM map. We found significant evidence for linkage of factor 1 to two regions on chromosome 6 near markers D6S403 (logarithm of odds [LOD] = 4.2) and D6S264 (LOD = 4.9). We also found strong evidence for linkage of factor 3 to a genetic location on chromosome 7 between markers D7S479 and D7S471 (LOD = 3.2). In conclusion, we found substantial evidence for susceptibility loci on chromosomes 6 and 7 that appear to influence the factors representing the IRS-related phenotypes in Mexican-Americans.

AB - Insulin resistance syndrome (IRS)-related phenotypes, such as hyperinsulinemia, obesity-related traits, impaired glucose tolerance, dyslipidemia, and hypertension, tend to cluster into factors. We attempted to identify loci influencing the factors of IRS-related phenotypes using phenotypic data from 261 nondiabetic subjects distributed across 27 low-income Mexican-American extended families. Principal component factor analyses were performed using eight IRS-related phenotypes: fasting glucose (FG), fasting specific insulin (FSI), BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), HDL cholesterol, In triglycerides (In TGs), and leptin (LEP). The factor analysis yielded three factors: factor 1 (BMI, LEP, and FSI), factor 2 (DBP and SBP), and factor 3 (HDL and In TG). We conducted multipoint variance components linkage analyses on these factors with the program SOLAR using a 10-15 cM map. We found significant evidence for linkage of factor 1 to two regions on chromosome 6 near markers D6S403 (logarithm of odds [LOD] = 4.2) and D6S264 (LOD = 4.9). We also found strong evidence for linkage of factor 3 to a genetic location on chromosome 7 between markers D7S479 and D7S471 (LOD = 3.2). In conclusion, we found substantial evidence for susceptibility loci on chromosomes 6 and 7 that appear to influence the factors representing the IRS-related phenotypes in Mexican-Americans.

UR - http://www.scopus.com/inward/record.url?scp=0036309976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036309976&partnerID=8YFLogxK

M3 - Article

C2 - 11872689

AN - SCOPUS:0036309976

VL - 51

SP - 841

EP - 847

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 3

ER -