Factors correlated with NPPV use in ALS

Carlayne E. Jackson; Steven Lovitt; Neelam Gowda; Frederick Anderson; Robert G. Miller; Walter G. Bradley; Mark B. Bromberg; Benjamin R. Brooks; Neil Cashman; Lora Clawson; Merit Cudkowicz; Dallas A. Forshew; Michael Graves; Terry Heiman-Patterson; Mary Lyon; Hiroshi Mitsumoto; Dan H. Moore; Steven P. Ringel; Jeffrey Rosenfeld; Mark A. Ross; Michael J. Strong; Robert L. Sufit; Valerie Cwik; Linda Boynton De Sepulveda; Yadollah Harati; Raul Mandler; Eric Pioro

doi:10.1080/14660820500504587

Factors correlated with NPPV use in ALS

Carlayne E. Jackson, Steven Lovitt, Neelam Gowda, Frederick Anderson, Robert G. Miller, Walter G. Bradley, Mark B. Bromberg, Benjamin R. Brooks, Neil Cashman, Lora Clawson, Merit Cudkowicz, Dallas A. Forshew, Michael Graves, Terry Heiman-Patterson, Mary Lyon, Hiroshi Mitsumoto, Dan H. Moore, Steven P. Ringel, Jeffrey Rosenfeld, Mark A. RossMichael J. Strong, Robert L. Sufit, Valerie Cwik, Linda Boynton De Sepulveda, Yadollah Harati, Raul Mandler, Eric Pioro

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

In spite of emerging evidence of therapeutic benefit from non-invasive positive pressure ventilation (NPPV), only a minority of ALS patients use this therapy. We examined factors which correlate with use of NPPV in ALS patients. Data were analyzed from the ALS CARE Database on the use of NPPV in patients with FVC less than 50% of predicted and probable or definite ALS based on modified El Escorial criteria. Of the 403 eligible patients, 146 (36%) used NPPV. NPPV compliance was strongly correlated with symptoms of dyspnea and orthopnea as well as with the use of other therapies including PEG tubes, augmentative speech devices, and riluzole. Male gender and household income >$80,000 were also associated with higher NPPV use. There was no correlation between age, race, type of insurance, forced vital capacity, duration of symptoms, ALSFRS-R, caregiver burden or quality of life with the use of NPPV. These data suggest that the factors which are most closely associated with NPPV utilization are symptomatic orthopnea and dyspnea. The findings may be useful in designing prospective studies to examine the factors which might explain the underutilization of NPPV and the optimal use of this treatment.

Original language	English (US)
Pages (from-to)	80-85
Number of pages	6
Journal	Amyotrophic Lateral Sclerosis
Volume	7
Issue number	2
DOIs	https://doi.org/10.1080/14660820500504587
State	Published - Jun 2006

Keywords

Amyotrophic lateral sclerosis
Bilevel positive airway pressure
Database
Management
Non-invasive positive pressure ventilation

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1080/14660820500504587

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Jackson, C. E., Lovitt, S., Gowda, N., Anderson, F., Miller, R. G., Bradley, W. G., Bromberg, M. B., Brooks, B. R., Cashman, N., Clawson, L., Cudkowicz, M., Forshew, D. A., Graves, M., Heiman-Patterson, T., Lyon, M., Mitsumoto, H., Moore, D. H., Ringel, S. P., Rosenfeld, J., ... Pioro, E. (2006). Factors correlated with NPPV use in ALS. Amyotrophic Lateral Sclerosis, 7(2), 80-85. https://doi.org/10.1080/14660820500504587

Jackson, CE, Lovitt, S, Gowda, N, Anderson, F, Miller, RG, Bradley, WG, Bromberg, MB, Brooks, BR, Cashman, N, Clawson, L, Cudkowicz, M, Forshew, DA, Graves, M, Heiman-Patterson, T, Lyon, M, Mitsumoto, H, Moore, DH, Ringel, SP, Rosenfeld, J, Ross, MA, Strong, MJ, Sufit, RL, Cwik, V, De Sepulveda, LB, Harati, Y, Mandler, R & Pioro, E 2006, 'Factors correlated with NPPV use in ALS', Amyotrophic Lateral Sclerosis, vol. 7, no. 2, pp. 80-85. https://doi.org/10.1080/14660820500504587

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title = "Factors correlated with NPPV use in ALS",

abstract = "In spite of emerging evidence of therapeutic benefit from non-invasive positive pressure ventilation (NPPV), only a minority of ALS patients use this therapy. We examined factors which correlate with use of NPPV in ALS patients. Data were analyzed from the ALS CARE Database on the use of NPPV in patients with FVC less than 50% of predicted and probable or definite ALS based on modified El Escorial criteria. Of the 403 eligible patients, 146 (36%) used NPPV. NPPV compliance was strongly correlated with symptoms of dyspnea and orthopnea as well as with the use of other therapies including PEG tubes, augmentative speech devices, and riluzole. Male gender and household income >$80,000 were also associated with higher NPPV use. There was no correlation between age, race, type of insurance, forced vital capacity, duration of symptoms, ALSFRS-R, caregiver burden or quality of life with the use of NPPV. These data suggest that the factors which are most closely associated with NPPV utilization are symptomatic orthopnea and dyspnea. The findings may be useful in designing prospective studies to examine the factors which might explain the underutilization of NPPV and the optimal use of this treatment.",

keywords = "Amyotrophic lateral sclerosis, Bilevel positive airway pressure, Database, Management, Non-invasive positive pressure ventilation",

author = "Jackson, {Carlayne E.} and Steven Lovitt and Neelam Gowda and Frederick Anderson and Miller, {Robert G.} and Bradley, {Walter G.} and Bromberg, {Mark B.} and Brooks, {Benjamin R.} and Neil Cashman and Lora Clawson and Merit Cudkowicz and Forshew, {Dallas A.} and Michael Graves and Terry Heiman-Patterson and Mary Lyon and Hiroshi Mitsumoto and Moore, {Dan H.} and Ringel, {Steven P.} and Jeffrey Rosenfeld and Ross, {Mark A.} and Strong, {Michael J.} and Sufit, {Robert L.} and Valerie Cwik and {De Sepulveda}, {Linda Boynton} and Yadollah Harati and Raul Mandler and Eric Pioro",

note = "Funding Information: The ALS Patient Care Database is supported by an unrestricted educational grant from Sanofi-Aventis Pharmaceuticals to the Center for Outcomes Research, University of Massachusetts Medical School",

year = "2006",

month = jun,

doi = "10.1080/14660820500504587",

language = "English (US)",

volume = "7",

pages = "80--85",

journal = "Amyotrophic Lateral Sclerosis",

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T1 - Factors correlated with NPPV use in ALS

AU - Jackson, Carlayne E.

AU - Lovitt, Steven

AU - Gowda, Neelam

AU - Anderson, Frederick

AU - Miller, Robert G.

AU - Bradley, Walter G.

AU - Bromberg, Mark B.

AU - Brooks, Benjamin R.

AU - Cashman, Neil

AU - Clawson, Lora

AU - Cudkowicz, Merit

AU - Forshew, Dallas A.

AU - Graves, Michael

AU - Heiman-Patterson, Terry

AU - Lyon, Mary

AU - Mitsumoto, Hiroshi

AU - Moore, Dan H.

AU - Ringel, Steven P.

AU - Rosenfeld, Jeffrey

AU - Ross, Mark A.

AU - Strong, Michael J.

AU - Sufit, Robert L.

AU - Cwik, Valerie

AU - De Sepulveda, Linda Boynton

AU - Harati, Yadollah

AU - Mandler, Raul

AU - Pioro, Eric

N1 - Funding Information: The ALS Patient Care Database is supported by an unrestricted educational grant from Sanofi-Aventis Pharmaceuticals to the Center for Outcomes Research, University of Massachusetts Medical School

PY - 2006/6

Y1 - 2006/6

N2 - In spite of emerging evidence of therapeutic benefit from non-invasive positive pressure ventilation (NPPV), only a minority of ALS patients use this therapy. We examined factors which correlate with use of NPPV in ALS patients. Data were analyzed from the ALS CARE Database on the use of NPPV in patients with FVC less than 50% of predicted and probable or definite ALS based on modified El Escorial criteria. Of the 403 eligible patients, 146 (36%) used NPPV. NPPV compliance was strongly correlated with symptoms of dyspnea and orthopnea as well as with the use of other therapies including PEG tubes, augmentative speech devices, and riluzole. Male gender and household income >$80,000 were also associated with higher NPPV use. There was no correlation between age, race, type of insurance, forced vital capacity, duration of symptoms, ALSFRS-R, caregiver burden or quality of life with the use of NPPV. These data suggest that the factors which are most closely associated with NPPV utilization are symptomatic orthopnea and dyspnea. The findings may be useful in designing prospective studies to examine the factors which might explain the underutilization of NPPV and the optimal use of this treatment.

AB - In spite of emerging evidence of therapeutic benefit from non-invasive positive pressure ventilation (NPPV), only a minority of ALS patients use this therapy. We examined factors which correlate with use of NPPV in ALS patients. Data were analyzed from the ALS CARE Database on the use of NPPV in patients with FVC less than 50% of predicted and probable or definite ALS based on modified El Escorial criteria. Of the 403 eligible patients, 146 (36%) used NPPV. NPPV compliance was strongly correlated with symptoms of dyspnea and orthopnea as well as with the use of other therapies including PEG tubes, augmentative speech devices, and riluzole. Male gender and household income >$80,000 were also associated with higher NPPV use. There was no correlation between age, race, type of insurance, forced vital capacity, duration of symptoms, ALSFRS-R, caregiver burden or quality of life with the use of NPPV. These data suggest that the factors which are most closely associated with NPPV utilization are symptomatic orthopnea and dyspnea. The findings may be useful in designing prospective studies to examine the factors which might explain the underutilization of NPPV and the optimal use of this treatment.

KW - Amyotrophic lateral sclerosis

KW - Bilevel positive airway pressure

KW - Database

KW - Management

KW - Non-invasive positive pressure ventilation

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U2 - 10.1080/14660820500504587

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M3 - Article

C2 - 16753971

AN - SCOPUS:33745101089

SN - 1748-2968

VL - 7

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EP - 85

JO - Amyotrophic Lateral Sclerosis

JF - Amyotrophic Lateral Sclerosis

IS - 2

ER -

Factors correlated with NPPV use in ALS

Abstract

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