Factors associated with change in exacerbation frequency in COPD

Gavin C. Donaldson, Hanna Müllerova, Nicholas Locantore, John R. Hurst, Peter M A Calverley, Jorgen Vestbo, Antonio R Anzueto, Jadwiga A. Wedzicha

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: Patients with chronic obstructive pulmonary disease (COPD) can be categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether they respectively experience two or more, or one or zero exacerbations per year. Although most patients do not change category from year to year, some will, and the factors associated with this behaviour have not been examined.Methods: 1832 patients completing two year follow-up in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study were examined at baseline and then yearly. Exacerbations were defined by health care utilisation. Patient characteristics compared between those patients who did or did not change exacerbation category from year 1 to year 2.Findings: Between years 1 and 2, 221 patients (17%) changed from IE to FE and 210 patients (39%) from FE to IE. More severe disease was associated with changing from IE to FE and less severe disease from FE to IE. Over the preceding year, small falls in FEV1 and 6-minute walking distance were associated with changing from IE to FE, and small falls in platelet count associated with changing from FE to IE.Conclusion: No parameter clearly predicts an imminent change in exacerbation frequency category.Trial registration: SCO104960, clinicaltrials.gov identifier NCT00292552.

Original languageEnglish (US)
Article number79
JournalRespiratory Research
Volume14
Issue number1
DOIs
StatePublished - Jul 30 2013

Fingerprint

Chronic Obstructive Pulmonary Disease
Patient Acceptance of Health Care
Platelet Count
Walking
Biomarkers

Keywords

  • COPD
  • Exacerbation frequency
  • Exacerbation phenotype
  • Exacerbations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Donaldson, G. C., Müllerova, H., Locantore, N., Hurst, J. R., Calverley, P. M. A., Vestbo, J., ... Wedzicha, J. A. (2013). Factors associated with change in exacerbation frequency in COPD. Respiratory Research, 14(1), [79]. https://doi.org/10.1186/1465-9921-14-79

Factors associated with change in exacerbation frequency in COPD. / Donaldson, Gavin C.; Müllerova, Hanna; Locantore, Nicholas; Hurst, John R.; Calverley, Peter M A; Vestbo, Jorgen; Anzueto, Antonio R; Wedzicha, Jadwiga A.

In: Respiratory Research, Vol. 14, No. 1, 79, 30.07.2013.

Research output: Contribution to journalArticle

Donaldson, GC, Müllerova, H, Locantore, N, Hurst, JR, Calverley, PMA, Vestbo, J, Anzueto, AR & Wedzicha, JA 2013, 'Factors associated with change in exacerbation frequency in COPD', Respiratory Research, vol. 14, no. 1, 79. https://doi.org/10.1186/1465-9921-14-79
Donaldson GC, Müllerova H, Locantore N, Hurst JR, Calverley PMA, Vestbo J et al. Factors associated with change in exacerbation frequency in COPD. Respiratory Research. 2013 Jul 30;14(1). 79. https://doi.org/10.1186/1465-9921-14-79
Donaldson, Gavin C. ; Müllerova, Hanna ; Locantore, Nicholas ; Hurst, John R. ; Calverley, Peter M A ; Vestbo, Jorgen ; Anzueto, Antonio R ; Wedzicha, Jadwiga A. / Factors associated with change in exacerbation frequency in COPD. In: Respiratory Research. 2013 ; Vol. 14, No. 1.
@article{87242c5428a24eb387083b946de3f2d5,
title = "Factors associated with change in exacerbation frequency in COPD",
abstract = "Background: Patients with chronic obstructive pulmonary disease (COPD) can be categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether they respectively experience two or more, or one or zero exacerbations per year. Although most patients do not change category from year to year, some will, and the factors associated with this behaviour have not been examined.Methods: 1832 patients completing two year follow-up in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study were examined at baseline and then yearly. Exacerbations were defined by health care utilisation. Patient characteristics compared between those patients who did or did not change exacerbation category from year 1 to year 2.Findings: Between years 1 and 2, 221 patients (17{\%}) changed from IE to FE and 210 patients (39{\%}) from FE to IE. More severe disease was associated with changing from IE to FE and less severe disease from FE to IE. Over the preceding year, small falls in FEV1 and 6-minute walking distance were associated with changing from IE to FE, and small falls in platelet count associated with changing from FE to IE.Conclusion: No parameter clearly predicts an imminent change in exacerbation frequency category.Trial registration: SCO104960, clinicaltrials.gov identifier NCT00292552.",
keywords = "COPD, Exacerbation frequency, Exacerbation phenotype, Exacerbations",
author = "Donaldson, {Gavin C.} and Hanna M{\"u}llerova and Nicholas Locantore and Hurst, {John R.} and Calverley, {Peter M A} and Jorgen Vestbo and Anzueto, {Antonio R} and Wedzicha, {Jadwiga A.}",
year = "2013",
month = "7",
day = "30",
doi = "10.1186/1465-9921-14-79",
language = "English (US)",
volume = "14",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Factors associated with change in exacerbation frequency in COPD

AU - Donaldson, Gavin C.

AU - Müllerova, Hanna

AU - Locantore, Nicholas

AU - Hurst, John R.

AU - Calverley, Peter M A

AU - Vestbo, Jorgen

AU - Anzueto, Antonio R

AU - Wedzicha, Jadwiga A.

PY - 2013/7/30

Y1 - 2013/7/30

N2 - Background: Patients with chronic obstructive pulmonary disease (COPD) can be categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether they respectively experience two or more, or one or zero exacerbations per year. Although most patients do not change category from year to year, some will, and the factors associated with this behaviour have not been examined.Methods: 1832 patients completing two year follow-up in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study were examined at baseline and then yearly. Exacerbations were defined by health care utilisation. Patient characteristics compared between those patients who did or did not change exacerbation category from year 1 to year 2.Findings: Between years 1 and 2, 221 patients (17%) changed from IE to FE and 210 patients (39%) from FE to IE. More severe disease was associated with changing from IE to FE and less severe disease from FE to IE. Over the preceding year, small falls in FEV1 and 6-minute walking distance were associated with changing from IE to FE, and small falls in platelet count associated with changing from FE to IE.Conclusion: No parameter clearly predicts an imminent change in exacerbation frequency category.Trial registration: SCO104960, clinicaltrials.gov identifier NCT00292552.

AB - Background: Patients with chronic obstructive pulmonary disease (COPD) can be categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether they respectively experience two or more, or one or zero exacerbations per year. Although most patients do not change category from year to year, some will, and the factors associated with this behaviour have not been examined.Methods: 1832 patients completing two year follow-up in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study were examined at baseline and then yearly. Exacerbations were defined by health care utilisation. Patient characteristics compared between those patients who did or did not change exacerbation category from year 1 to year 2.Findings: Between years 1 and 2, 221 patients (17%) changed from IE to FE and 210 patients (39%) from FE to IE. More severe disease was associated with changing from IE to FE and less severe disease from FE to IE. Over the preceding year, small falls in FEV1 and 6-minute walking distance were associated with changing from IE to FE, and small falls in platelet count associated with changing from FE to IE.Conclusion: No parameter clearly predicts an imminent change in exacerbation frequency category.Trial registration: SCO104960, clinicaltrials.gov identifier NCT00292552.

KW - COPD

KW - Exacerbation frequency

KW - Exacerbation phenotype

KW - Exacerbations

UR - http://www.scopus.com/inward/record.url?scp=84881101135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881101135&partnerID=8YFLogxK

U2 - 10.1186/1465-9921-14-79

DO - 10.1186/1465-9921-14-79

M3 - Article

C2 - 23899210

AN - SCOPUS:84881101135

VL - 14

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

IS - 1

M1 - 79

ER -