F-box proteins in flowering plants

Hongyun Wang, Jian Huang, Zhao Lai, Yongbiao Xue

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


In eukaryotes, the ubiquitin-mediated protein degradation pathway has been shown to control several key biological processes such as cell division, development, metabolism and immune response. F-box proteins, as a part of SCF (Skp1-Cullin (or Cdc53)-F-box) complex, functioned by interacting with substrate proteins, leading to their subsequent degradation by the 26S proteasome. To date, several F-box proteins identified in Arabidopsis and Antirrhinum have been shown to play important roles in auxin signal transduction, floral organ formation, flowering and leaf senescence. Arabidopsis genome sequence analysis revealed that it encodes over 1000 predicted F-box proteins accounting for about 5% of total predicted proteins. These results indicate that the ubiquitin-mediated protein degradation involving the F-box proteins is an important mechanism controlling plant gene expression. Here, we review the known F-box proteins and their functions in flowering plants.

Original languageEnglish (US)
Pages (from-to)1497-1501
Number of pages5
JournalChinese Science Bulletin
Issue number18
StatePublished - Sep 2002
Externally publishedYes


  • Auxin signal transduction
  • F-box protein
  • Proteolysis
  • SCF complex

ASJC Scopus subject areas

  • General


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