Extrinsic stain removal efficacy of a stannous fluoride dentifrice with sodium hexametaphosphate

Tao He, Robert Baker, Robert D. Bartizek, Aaron R. Biesbrock, Eros Chaves, Geza T Terezhalmy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Two randomized, six-week, double-blind, parallel group, clinical trials were independently conducted to compare the extrinsic stain removal efficacy of a novel whitening therapeutic dentifrice containing 0.454% stannous fluoride and sodium hexametaphosphate in a formulation with high cleaning silica, relative to a positive control whitening dentifrice. Methodology: Generally healthy adults, 56 for study 1 and 60 for study 2, with visible extrinsic tooth stain were enrolled in the studies. At the baseline visit, stain was assessed on the facial surfaces of the eight central and lateral incisors using the modified Lobene Stain Index. Oral soft and hard tissue examinations were also conducted. In each study, subjects were randomized to either the stannous fluoride + sodium hexametaphosphate toothpaste (Crest® Pro-Health®) or the positive control toothpaste (Colgate® Total® Plus Whitening) to use twice per day for six weeks. Stain and safety were reassessed at weeks three and six. Results: Fifty-two and 58 subjects completed studies 1 and 2, respectively. In each study, there were no statistically significant differences in Lobene composite stain scores between the two treatment groups across all three visits. Both groups showed statistically significant reductions in Lobene composite stain scores at week three (p < 0.0001) and week six (p < 0.0001) relative to baseline. The percent of Lobene composite scores with a greater than 0.5 unit reduction from baseline at week six was 86% for study 1 and 97% for study 2 for the stannous fluoride + sodium hexametaphosphate dentifrice group. Conclusion: Collectively, these two stain removal clinical trials demonstrate the statistically significant extrinsic stain removal efficacy for the stannous fluoride + sodium hexametaphosphate dentifrice relative to baseline. There were no statistically significant differences between the stannous fluoride + sodium hexametaphosphate dentifrice and positive control treatment group.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalJournal of Clinical Dentistry
Volume18
Issue number1
StatePublished - 2007

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Tin Fluorides
Dentifrices
Coloring Agents
Clinical Trials
Toothpastes
sodium polymetaphosphate
Incisor
Silicon Dioxide
Tooth

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

He, T., Baker, R., Bartizek, R. D., Biesbrock, A. R., Chaves, E., & Terezhalmy, G. T. (2007). Extrinsic stain removal efficacy of a stannous fluoride dentifrice with sodium hexametaphosphate. Journal of Clinical Dentistry, 18(1), 7-11.

Extrinsic stain removal efficacy of a stannous fluoride dentifrice with sodium hexametaphosphate. / He, Tao; Baker, Robert; Bartizek, Robert D.; Biesbrock, Aaron R.; Chaves, Eros; Terezhalmy, Geza T.

In: Journal of Clinical Dentistry, Vol. 18, No. 1, 2007, p. 7-11.

Research output: Contribution to journalArticle

He, T, Baker, R, Bartizek, RD, Biesbrock, AR, Chaves, E & Terezhalmy, GT 2007, 'Extrinsic stain removal efficacy of a stannous fluoride dentifrice with sodium hexametaphosphate', Journal of Clinical Dentistry, vol. 18, no. 1, pp. 7-11.
He T, Baker R, Bartizek RD, Biesbrock AR, Chaves E, Terezhalmy GT. Extrinsic stain removal efficacy of a stannous fluoride dentifrice with sodium hexametaphosphate. Journal of Clinical Dentistry. 2007;18(1):7-11.
He, Tao ; Baker, Robert ; Bartizek, Robert D. ; Biesbrock, Aaron R. ; Chaves, Eros ; Terezhalmy, Geza T. / Extrinsic stain removal efficacy of a stannous fluoride dentifrice with sodium hexametaphosphate. In: Journal of Clinical Dentistry. 2007 ; Vol. 18, No. 1. pp. 7-11.
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AU - Chaves, Eros

AU - Terezhalmy, Geza T

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N2 - Objective: Two randomized, six-week, double-blind, parallel group, clinical trials were independently conducted to compare the extrinsic stain removal efficacy of a novel whitening therapeutic dentifrice containing 0.454% stannous fluoride and sodium hexametaphosphate in a formulation with high cleaning silica, relative to a positive control whitening dentifrice. Methodology: Generally healthy adults, 56 for study 1 and 60 for study 2, with visible extrinsic tooth stain were enrolled in the studies. At the baseline visit, stain was assessed on the facial surfaces of the eight central and lateral incisors using the modified Lobene Stain Index. Oral soft and hard tissue examinations were also conducted. In each study, subjects were randomized to either the stannous fluoride + sodium hexametaphosphate toothpaste (Crest® Pro-Health®) or the positive control toothpaste (Colgate® Total® Plus Whitening) to use twice per day for six weeks. Stain and safety were reassessed at weeks three and six. Results: Fifty-two and 58 subjects completed studies 1 and 2, respectively. In each study, there were no statistically significant differences in Lobene composite stain scores between the two treatment groups across all three visits. Both groups showed statistically significant reductions in Lobene composite stain scores at week three (p < 0.0001) and week six (p < 0.0001) relative to baseline. The percent of Lobene composite scores with a greater than 0.5 unit reduction from baseline at week six was 86% for study 1 and 97% for study 2 for the stannous fluoride + sodium hexametaphosphate dentifrice group. Conclusion: Collectively, these two stain removal clinical trials demonstrate the statistically significant extrinsic stain removal efficacy for the stannous fluoride + sodium hexametaphosphate dentifrice relative to baseline. There were no statistically significant differences between the stannous fluoride + sodium hexametaphosphate dentifrice and positive control treatment group.

AB - Objective: Two randomized, six-week, double-blind, parallel group, clinical trials were independently conducted to compare the extrinsic stain removal efficacy of a novel whitening therapeutic dentifrice containing 0.454% stannous fluoride and sodium hexametaphosphate in a formulation with high cleaning silica, relative to a positive control whitening dentifrice. Methodology: Generally healthy adults, 56 for study 1 and 60 for study 2, with visible extrinsic tooth stain were enrolled in the studies. At the baseline visit, stain was assessed on the facial surfaces of the eight central and lateral incisors using the modified Lobene Stain Index. Oral soft and hard tissue examinations were also conducted. In each study, subjects were randomized to either the stannous fluoride + sodium hexametaphosphate toothpaste (Crest® Pro-Health®) or the positive control toothpaste (Colgate® Total® Plus Whitening) to use twice per day for six weeks. Stain and safety were reassessed at weeks three and six. Results: Fifty-two and 58 subjects completed studies 1 and 2, respectively. In each study, there were no statistically significant differences in Lobene composite stain scores between the two treatment groups across all three visits. Both groups showed statistically significant reductions in Lobene composite stain scores at week three (p < 0.0001) and week six (p < 0.0001) relative to baseline. The percent of Lobene composite scores with a greater than 0.5 unit reduction from baseline at week six was 86% for study 1 and 97% for study 2 for the stannous fluoride + sodium hexametaphosphate dentifrice group. Conclusion: Collectively, these two stain removal clinical trials demonstrate the statistically significant extrinsic stain removal efficacy for the stannous fluoride + sodium hexametaphosphate dentifrice relative to baseline. There were no statistically significant differences between the stannous fluoride + sodium hexametaphosphate dentifrice and positive control treatment group.

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