Extrauterine mixed mesodermal tumors. An immunohistochemical study

E. A. Dellers, P. T. Valente, P. R. Edmonds, G. Balsara

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Mixed mesodermal tumors are uncommon outside the uterus. Nine extrauterine mixed mesodermal tumors (eight ovarian and one extra-genital) were selected for histochemical and immunoperoxidase study. In eight cases, both epithelial and mesenchymal elements were malignant (chondroid in six, rhabdomyoid in four, and osteoid in two). One ovarian tumor was an adenosarcoma. All cases were stained with periodic acid-Schiff with and without diastase and for α1-antitrypsin, myoglobin, keratin, vimentin, muscle-specific actin, and α1-antichymotrypsin, by using the avidin-biotin-immunoperoxidase method. The periodic acid - Schiff-positive, diastase-resistant droplets in several of the tumors showed peripheral α1-antitrypsin positivity. Keratin delineated epithelial areas well in seven cases, and rhabdomyoid differentiation was confirmed with myoglobin in four cases. However, squamous elements in one tumor were falsely positive for myoglobin. We concluded that despite occasional cross-reactivity, carefully interpreted immunoperoxidase stains can be useful in distinguishing epithelial and mesenchymal elements in these tumors.

Original languageEnglish (US)
Pages (from-to)918-920
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number9
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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