External beam irradiation for inhibition of intimal hyperplasia following prosthetic bypass: Preliminary results

Karl A. Illig, Jacqueline P. Williams, Sean P. Lyden, Eric Hernady, Arvind Soni, Mark G. Davies, Michael Schell, Paul Okunieff, Philip Rubin, Richard M. Green

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

To determine whether external beam irradiation delivered immediately after graft implantation can inhibit anastomotic intimal hyperplasia (IH) 1 month following polytetrafluoroethylene (PTFE) bypass in a sheep carotid artery model, 23 sheep underwent bilateral bypass of the ligated common carotid artery with 8-mm PTFE immediately followed by a single dose of irradiation (15, 21, or 30 Gy) to one side. The 15 animals with bilaterally patent grafts were euthanized at 1 month and graft-arterial anastomoses harvested. Using computer-aided image analysis, IH areas and thicknesses were measured. Graft patency in this model was 83% at 1 month and did not differ according to treatment administered. In the control animals, IH was greatest at mid-anastomosis, but minimal within the native vessel. All three radiation doses markedly inhibited mid-anastomotic IH area and thickness. At the proximal anastomosis, 30 Gy reduced the IH area 20-fold, from 2.06 to 0.14 mm2 (p<0.0001 by ANOVA), and IH thickness 70-fold, from 29.0 to 0.4 μm (p<0.0002); similar effects were seen at the distal anastomosis. No adverse effects of radiation treatment were observed. External beam irradiation in doses of 15 to 30 Gy delivered in a single fraction immediately after operation markedly inhibits development of intimal hyperplasia 1 month following end-to-side anastomosis with PTFE in sheep.

Original languageEnglish (US)
Pages (from-to)533-538
Number of pages6
JournalAnnals of Vascular Surgery
Volume15
Issue number5
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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