TY - JOUR
T1 - Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q
AU - Larsen, Pamela L.
AU - Clarke, Catherine F.
PY - 2002/1/4
Y1 - 2002/1/4
N2 - The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by ∼60%. The longevity of clk-1, daf-2, daf-12, and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span determination. The findings suggest that Q and the daf-2 pathway intersect at the mitochondria and imply that a concerted production coupled with enhanced scavenging of reactive oxygen species contributes to the substantial life-span extension.
AB - The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by ∼60%. The longevity of clk-1, daf-2, daf-12, and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span determination. The findings suggest that Q and the daf-2 pathway intersect at the mitochondria and imply that a concerted production coupled with enhanced scavenging of reactive oxygen species contributes to the substantial life-span extension.
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U2 - 10.1126/science.1064653
DO - 10.1126/science.1064653
M3 - Article
C2 - 11778046
AN - SCOPUS:0037016442
SN - 0036-8075
VL - 295
SP - 120
EP - 123
JO - Science
JF - Science
IS - 5552
ER -