Extended-spectrum β-lactamases: Epidemiology, detection, and treatment

S. Nathisuwan, D. S. Burgess, J. S. Lewis

    Research output: Contribution to journalReview articlepeer-review

    132 Scopus citations

    Abstract

    Extended-spectrum β-lactamases (ESBLs) are extremely broad spectrum β-lactamase enzymes found in a variety of Enterobacteriaceae. Most strains producing these β-lactamases are Klebsiella pneumoniae, other Klebsiella species (i.e., K. oxytoca), and Escherichia coli. When producing these enzymes, organisms become highly effective at inactivating various β-lactam antibiotics. In addition, ESBL-producing bacteria are frequently resistant to many classes of antibiotics, resulting in difficult-to-treat infections. Other problems due to ESBL-producing bacteria are difficulty in detecting the presence of ESBLs, limited treatment options, and deleterious impact on clinical outcomes. Clinicians should be familiar with the clinical significance of these enzymes and potential strategies for dealing with this growing problem.

    Original languageEnglish (US)
    Pages (from-to)920-928
    Number of pages9
    JournalPharmacotherapy
    Volume21
    Issue number8
    DOIs
    StatePublished - Jan 1 2001

    ASJC Scopus subject areas

    • Pharmacology (medical)

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