Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes

A. J. Hulbert, Sally C. Faulks, James M. Harper, Richard A. Miller, Rochelle Buffenstein

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Two lines of mice, Idaho (Id) and Majuro (Ma), both derived from wild-trapped progenitors, have previously been shown to have extended lifespans in captivity when compared to a genetically heterogenous laboratory line of mice (DC). We have examined whether membrane fatty composition varies with lifespan within the species Mus musculus in a similar manner to that previously demonstrated between mammal species. Muscle and liver phospholipids from these long-living mice lines have a reduced amount of the highly polyunsaturated omega-3 docosahexaenoic acid compared to the DC mice, and consequently their membranes are less likely to peroxidative damage. The relationship between maximum longevity and membrane peroxidation index is similar for these mice lines as previously observed for mammals in general. It is suggested that peroxidation-resistant membranes may be an important component of extended longevity.

Original languageEnglish (US)
Pages (from-to)653-657
Number of pages5
JournalMechanisms of Ageing and Development
Volume127
Issue number8
DOIs
StatePublished - Aug 2006

Keywords

  • Docosahexaenoic acid
  • Lipid peroxidation
  • Maximum lifespan
  • Membranes

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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