Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives

H. Dang, M. Takei, D. Isenberg, Y. Shoenfeld, R. Backimer, J. Rauch, N. Talal

Research output: Contribution to journalArticle

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Abstract

Sera from 29 SLE patients and 81 first-degree healthy family members were tested for quantitative expression of a cross-reactive idiotype present on a murine monoclonal anti-Sm autoantibody (Y2). Forty-one percent of SLE patients and 27% of all relatives showed increased serum levels of the Y2 idiotype compared to 6% in a normal, unrelated control group. In addition, female relatives of SLE patients showed slightly increased levels of anti-Sm antibodies compared to male relatives (15% vs 3%). In one of the 28 families and three unrelated SLE patients studied, there was a significant correlation between the Y2 idiotype expression and expression of another idiotype present on anti-DNA antibodies (1341d). Affinity column absorption studies showed that these two idiotypes were present on different antibody molecules. This study demonstrates: (1) a genetic predisposition for an anti-Sm antibody idiotype expression in humans; and (2) that two different idiotypes may be under parallel or coordinate regulation.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalClinical and Experimental Immunology
Volume71
Issue number3
StatePublished - 1988

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Serum
Anti-Idiotypic Antibodies
Antinuclear Antibodies
Genetic Predisposition to Disease
Autoantibodies
Control Groups
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Dang, H., Takei, M., Isenberg, D., Shoenfeld, Y., Backimer, R., Rauch, J., & Talal, N. (1988). Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives. Clinical and Experimental Immunology, 71(3), 445-450.

Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives. / Dang, H.; Takei, M.; Isenberg, D.; Shoenfeld, Y.; Backimer, R.; Rauch, J.; Talal, N.

In: Clinical and Experimental Immunology, Vol. 71, No. 3, 1988, p. 445-450.

Research output: Contribution to journalArticle

Dang, H, Takei, M, Isenberg, D, Shoenfeld, Y, Backimer, R, Rauch, J & Talal, N 1988, 'Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives', Clinical and Experimental Immunology, vol. 71, no. 3, pp. 445-450.
Dang H, Takei M, Isenberg D, Shoenfeld Y, Backimer R, Rauch J et al. Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives. Clinical and Experimental Immunology. 1988;71(3):445-450.
Dang, H. ; Takei, M. ; Isenberg, D. ; Shoenfeld, Y. ; Backimer, R. ; Rauch, J. ; Talal, N. / Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives. In: Clinical and Experimental Immunology. 1988 ; Vol. 71, No. 3. pp. 445-450.
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