Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives

H. Dang, M. Takei, D. Isenberg, Y. Shoenfeld, R. Backimer, J. Rauch, N. Talal

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Sera from 29 SLE patients and 81 first-degree healthy family members were tested for quantitative expression of a cross-reactive idiotype present on a murine monoclonal anti-Sm autoantibody (Y2). Forty-one percent of SLE patients and 27% of all relatives showed increased serum levels of the Y2 idiotype compared to 6% in a normal, unrelated control group. In addition, female relatives of SLE patients showed slightly increased levels of anti-Sm antibodies compared to male relatives (15% vs 3%). In one of the 28 families and three unrelated SLE patients studied, there was a significant correlation between the Y2 idiotype expression and expression of another idiotype present on anti-DNA antibodies (1341d). Affinity column absorption studies showed that these two idiotypes were present on different antibody molecules. This study demonstrates: (1) a genetic predisposition for an anti-Sm antibody idiotype expression in humans; and (2) that two different idiotypes may be under parallel or coordinate regulation.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalClinical and Experimental Immunology
Volume71
Issue number3
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives'. Together they form a unique fingerprint.

  • Cite this

    Dang, H., Takei, M., Isenberg, D., Shoenfeld, Y., Backimer, R., Rauch, J., & Talal, N. (1988). Exression of an interspecies idiotype in sera of SLE patients and their first-degree relatives. Clinical and Experimental Immunology, 71(3), 445-450.