Expression of three viral oncogenes (v-sis, v-myc, v-fos) in primary human brain tumors of neuroectodermal origin

M. Fujimoto, F. J. Weaker, D. C. Herbert, Z. D. Sharp, P. J. Sheridan, J. L. Story

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We determined which viral oncogenes (v-sis, v-myc, and v-fos) were expressed in five primary human brain tumors of neuroectodermal origin (two glioblastomas multiforme, one medulloblastoma, one cystic cerebellar astrocytoma, and one ganglioglioma) and which of these oncogenes is correlated with malignancy. Using the dot hybridization technique, we determined the relative amounts of mRNA coded by these genes using the same nitrocellulose filter. The v-myc probe showed a 4-to 12-fold greater hybridization to the mRNA from two glioblastomas and the medulloblastoma (malignant group) than the mRNA from the cystic cerebellar astrocytoma or the ganglioglioma (benign group). In contrast, RNA hybridizing to v-sis and v-fos were accumulated to a greater extent in the benign tumors. These data suggest that the amount of myc expression may be correlated with the degree of malignancy of brain tumors of neuroectodermal origin.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalNeurology
Volume38
Issue number2
DOIs
StatePublished - Feb 1988

ASJC Scopus subject areas

  • Clinical Neurology

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