Expression of the BMP 2 gene during bone cell differentiation

N. Ghosh-Choudhury, M. A. Harris, J. Q. Feng, G. R. Mundy, S. E. Harris

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Bone morphogenetic protein 2 (BMP 2) and transforming growth factor β (TGFβ) am actively involved in bone formation and remodeling. TGFβ, a powerful stimulant in the early stage of bone cell growth and matrix formation, inhibits differentiation and in vitro mineralized nodule formation in primary fetal rat calvarial osteoblast system. TGFβ also negatively regulates BMP 2 expression at the transcriptional level. BMP 2 gene expression is controlled by a battery of transcriptional factors, some known and some yet to be identified. Immortalized osteoblast cell lines generated from a transgenic mouse carrying BMP 2 promoter-driven SV40 large T antigen transgene are described as powerful tools for studying regulation of BMP 2 gene expression and bone cell differentiation at the molecular level.

Original languageEnglish (US)
Pages (from-to)345-355
Number of pages11
JournalCritical Reviews in Eukaryotic Gene Expression
Volume4
Issue number2-3
DOIs
StatePublished - 1994

Keywords

  • BMP 2 promoter
  • TGFβ
  • bone morphogenetic proteins
  • transgenic bone cell lines

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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